Pharmacogenetics of nevirapine-associated hepatotoxicity: An adult AIDS Clinical Trials Group Collaboration

Associations have been reported between an MDR1 variant and responses to nonnucleoside reverse-transcriptase inhibitors. We explored associations between MDR1, CYP2B6, and CYP3A polymorphisms and nevirapine hepatotoxicity. Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C→T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P = .016). © 2006 by the Infectious Diseases Society of America. All rights reserved.