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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunotherapy with Mycobacterium vaccae as an addition to chemotherapy for the treatment of pulmonary tuberculosis under difficult conditions in Africa
Respiratory Medicine, Volume 89, No. 3, Year 1995
Notification
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Description
A study to assess the impact of immunotherapy with Mycobacterium vaccae on the treatment of pulmonary tuberculosis was conducted under existing conditions in Kano, a large city in Northern Nigeria. Whilst it did not quite meet all the criteria of a well-controlled randomized or double-blind trial, the study produced results suggestive of a successful intervention. Immunotherapy with M. vaccae had a beneficial influence on clinical recovery and survival, whether given after 1, 2 or 3 weeks of chemotherapy, according to an assessment made 10-14 months after treatment. Approximately 3 weeks (19·8 days) after the onset of chemotherapy (SHRZ), 73% of the patients who received immunotherapy and 19% of those who received placebo (chemotherapy alone) had become sputum negative by microscopy for acid-fast bacilli (AFB). Similarly, a mean fall in erythrocyte sedimentation rate (ESR) of 25·4 ± 2·50 mm and 4·0 ± 2·29 mm was observed in the immunotherapy and placebo recipients respectively, at the same time of assessment. When weight was assessed in the two groups, it was observed that 3 weeks after starting chemotherapy, the recipients of immunotherapy had a mean weight gain of 2·90 ± 0·24 kg whilst placebo recipients had a mean weight gain of only 0·55 ± 0·17 kg. These parameters were re-evaluated, 10-14 months later. They showed that 11% of the recipients of the active intervention and 84·6% of placebo recipients still had demonstrable AFB in their sputum. The mean weight gain had increased to 7·91 ± 1·03 kg and 2·04 ± 0·94 kg in the immunotherapy and placebo recipients respectively. The recorded mortality amongst those traced in this second follow-up was 40% for the placebo recipients and 0% for the recipients of immunotherapy. The impact of immunotherapy is discussed against the backdrop of a high mortality rate from tuberculosis, resulting from the absence of the most basic of anti-TB medication in the hospital, a preponderance of fake drugs in the open markets and local chemist stores as well as the rising seroprevalence of HIV and AIDS. © 1995.
Authors & Co-Authors
Onyebujoh, Philip Chukwuka
United Kingdom, London
Ucl Medical School
Abdulmumini, T.
Nigeria, Kano
Infectious Diseases Hospital
Robinson, S.
United Kingdom, London
The Royal Free Hospital
Rook, Graham A.W.
United Kingdom, London
Ucl Medical School
Stanford, John L.
United Kingdom, London
Ucl Medical School
Statistics
Citations: 63
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/0954-6111(95)90248-1
ISSN:
09546111
Research Areas
Cancer
Disability
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Nigeria