Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Virus nomenclature below the species level: A standardized nomenclature for filovirus strains and variants rescued from cDNA
Archives of Virology, Volume 159, No. 5, Year 2014
Notification
URL copied to clipboard!
Description
Specific alterations (mutations, deletions, insertions) of virus genomes are crucial for the functional characterization of their regulatory elements and their expression products, as well as a prerequisite for the creation of attenuated viruses that could serve as vaccine candidates. Virus genome tailoring can be performed either by using traditionally cloned genomes as starting materials, followed by site-directed mutagenesis, or by de novo synthesis of modified virus genomes or parts thereof. A systematic nomenclature for such recombinant viruses is necessary to set them apart from wild-type and laboratory-adapted viruses, and to improve communication and collaborations among researchers who may want to use recombinant viruses or create novel viruses based on them. A large group of filovirus experts has recently proposed nomenclatures for natural and laboratory animal-adapted filoviruses that aim to simplify the retrieval of sequence data from electronic databases. Here, this work is extended to include nomenclature for filoviruses obtained in the laboratory via reverse genetics systems. The previously developed template for natural filovirus genetic variant naming,
(
/)
/
/
/
-
, is retained, but we propose to adapt the type of information added to each field for cDNA clone-derived filoviruses. For instance, the full-length designation of an Ebola virus Kikwit variant rescued from a plasmid developed at the US Centers for Disease Control and Prevention could be akin to "Ebola virus H.sapiens-rec/COD/1995/Kikwit-abc1" (with the suffix "rec" identifying the recombinant nature of the virus and "abc1" being a placeholder for any meaningful isolate designator). Such a full-length designation should be used in databases and the methods section of publications. Shortened designations (such as "EBOV H.sap/COD/95/Kik-abc1") and abbreviations (such as "EBOV/Kik-abc1") could be used in the remainder of the text, depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed. © 2013 Springer-Verlag Wien (outside the USA).
Authors & Co-Authors
Kuhn, Jens H.
Unknown Affiliation
Bào, Yiming
Unknown Affiliation
Bavari, Sina
Unknown Affiliation
Becker, Stephan
Unknown Affiliation
Bradfute, Steven B.
Unknown Affiliation
Brauburger, Kristina
Unknown Affiliation
Brister, James Rodney
Unknown Affiliation
Bukreyev, Alexander A.
Unknown Affiliation
Caì, Yíngyún
Unknown Affiliation
Chandran, Kartik
Unknown Affiliation
Davey, Robert A.
Unknown Affiliation
Dolnik, Olga
Unknown Affiliation
Dye, John M.
Unknown Affiliation
Enterlein, Sven
Unknown Affiliation
Gonzalez, J. P.
Unknown Affiliation
Formenty, Pierre Bernard Henri
Unknown Affiliation
Freiberg, Alexander N.
Unknown Affiliation
Hensley, Lisa E.
Unknown Affiliation
Hoenen, Thomas
Unknown Affiliation
Honko, Anna N.
Unknown Affiliation
Ignatyev, Georgy M.
Unknown Affiliation
Jährling, Peter B.
Unknown Affiliation
Johnson, Karl M.
Unknown Affiliation
Klenk, Hans Dieter
Unknown Affiliation
Kobinger, Gary P.
Unknown Affiliation
Lackemeyer, Matthew G.
Unknown Affiliation
Leroy, Éric Maurice
Unknown Affiliation
Lever, Mark S.
Unknown Affiliation
Mühlberger, Elke
Unknown Affiliation
Netesov, Sergey V.
Unknown Affiliation
Olinger, Gene G.
Unknown Affiliation
Palacios, Gustavo F.
Unknown Affiliation
Patterson, Jean L.
Unknown Affiliation
Pawȩska, Janusz Tadeusz
Unknown Affiliation
Pitt, Margaret Louise M.
Unknown Affiliation
Radoshitzky, Sheli R.
Unknown Affiliation
Ryabchikova, Elena I.
Unknown Affiliation
Saphire, Erica Ollmann
Unknown Affiliation
Shestopalov, Aleksandr M.
Unknown Affiliation
Smither, Sophie J.
Unknown Affiliation
Sullivan, Nancy J.
Unknown Affiliation
Swanepoel, Robert
Unknown Affiliation
Takada, Ayato
Unknown Affiliation
Towner, Jonathan S.
Unknown Affiliation
van der Groen, Guido S.R.
Unknown Affiliation
Volchkov, Viktor E.
Unknown Affiliation
Volchkova, Valentina A.
Unknown Affiliation
Wahl, Victoria
Unknown Affiliation
Warren, Travis K.
Unknown Affiliation
Warfield, Kelly L.
Unknown Affiliation
Weidmann, Manfred W.
Unknown Affiliation
Nichol, Stuart T.
Unknown Affiliation
Statistics
Citations: 73
Authors: 52
Affiliations: 30
Identifiers
Doi:
10.1007/s00705-013-1877-2
ISSN:
03048608
Research Areas
Genetics And Genomics
Infectious Diseases