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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Moonlighting kinases with guanylate cyclase activity can tune regulatory signal networks
Plant Signaling and Behavior, Volume 7, No. 2, Year 2012
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Description
Guanylate cyclase (GC) catalyzes the formation of cGMP and it is only recently that such enzymes have been characterized in plants. One family of plant GCs contains the GC catalytic center encapsulated within the intracellular kinase domain of leucine rich repeat receptor like kinases such as the phytosulfokine and brassinosteroid receptors. In vitro studies show that both the kinase and GC domain have catalytic activity indicating that these kinase-GCs are examples of moonlighting proteins with dual catalytic function. The natural ligands for both receptors increase intracellular cGMP levels in isolated mesophyll protoplast assays suggesting that the GC activity is functionally relevant. cGMP production may have an autoregulatory role on receptor kinase activity and/or contribute to downstream cell expansion responses. We postulate that the receptors are members of a novel class of receptor kinases that contain functional moonlighting GC domains essential for complex signaling roles. © 2012 Landes Bioscience.
Authors & Co-Authors
Irving, Helen R.
Australia, Melbourne
Monash Institute of Pharmaceutical Sciences
Kwezi, Lusisizwe
Australia, Melbourne
Monash Institute of Pharmaceutical Sciences
South Africa, Potchefstroom
North-west University
Wheeler, Janet I.
Australia, Melbourne
Monash Institute of Pharmaceutical Sciences
Gehring, Chris A.
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Statistics
Citations: 41
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.4161/psb.18891
ISSN:
15592316
e-ISSN:
15592324