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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Calcium pyrophosphate crystal deposition in the ligamentum flavum of degenerated lumbar spine: Histopathological and immunohistological findings
Clinical Rheumatology, Volume 27, No. 5, Year 2008
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Description
We investigated the histological and immunohistochemical features of degenerative changes in the ligamentum flavum of the lumbar spine with calcium crystal deposition. We investigated degenerative changes in 270 ligamentum flavum specimens harvested from 198 patients who underwent decompressive surgeries for lumbar spinal canal stenosis. En bloc sections of the ligamentum flavum were examined histologically. We also examined immunoreactivity for transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), CD34, and CD68; immunoblot analysis for VEGF; and terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick end-labeling (TUNEL) method. The ligamentum flavum showed fragmented and disorganized elastic fiber bundles with increased collagen fibrils in the matrix. Calcium deposition, which was identified as calcium pyrophosphate dihydrate crystals, was evident in 72 of 198 patients and in 99 of 270 samples, and was associated with appearance of hypertrophic chondrocytes and new blood vessel formation. Areas of calcium deposits were surrounded by abundant hypertrophic chondrocytes (with marked immunoreactivity to TGF-β and VEGF) and a significant number of TUNEL-positive chondrocytes. Calcium crystal deposition in the lumbar ligamentum flavum progresses with reduction in elastic fibers and accumulation of collagen fibrils in the matrix as well as expansion of chondrometaplastic areas. © Clinical Rheumatology 2007.
Authors & Co-Authors
Yayama, Takafumi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Kobayashi, Shigeru
Japan, Eiheiji
University of Fukui School of Medical Sciences
Sato, Ryuichiro
Japan, Eiheiji
University of Fukui School of Medical Sciences
Uchida, Kenzou
Japan, Eiheiji
University of Fukui School of Medical Sciences
Kokubo, Yasuro
Japan, Eiheiji
University of Fukui School of Medical Sciences
Nakajima, Hideaki
Japan, Eiheiji
University of Fukui School of Medical Sciences
Takamura, Takaharu
Japan, Eiheiji
University of Fukui School of Medical Sciences
Mwaka, Erisa Sabakaki
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Orwotho, Norbert T.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Baba, Hisatoshi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Statistics
Citations: 36
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1007/s10067-007-0754-3
ISSN:
07703198