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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of food on the steady-state pharmacokinetics of tenofovir and emtricitabine plus efavirenz in ugandan adults
AIDS Research and Treatment, Volume 2012, Article 105980, Year 2012
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Description
We investigated the effect of food on the steady-state pharmacokinetics of a proprietary fixed-dose combination (FDC) tablet containing tenofovir disoproxil fumarate (TDF)/emtricitabine/efavirenz. Fifteen Ugandan HIV-1 patients at steady-state dosing with TDF/emtricitabine/efavirenz were admitted for 24-hour intensive pharmacokinetic sampling after dosing in the fasting state. Blood sampling was repeated seven days later with TDF/emtricitabine/ efavirenz administered with food (19 g fat). Drug concentrations in plasma were determined by liquid chromatography and tandem mass spectrometry. Geometric mean ratios (GMRs) and confidence intervals (CIs) of parameters were calculated (reference, fasting). For efavirenz, GMRs (90% CIs) for C max, AUC 0 - 24, and C were 1.47 (1.24-1.75), 1.13 (1.03-1.23), and 1.01 (0.91-1.11), respectively. Corresponding GMRs were 1.04 (0.84-1.27), 1.19 (1.10-1.29), and 0.99 (0.82-1.19) for tenofovir, 0.83 (0.76-0.92), 0.87 (0.78-0.97), and 0.91 (0.73-1.14) for emtricitabine. Stable patients may take the FDC without meal restrictions. The FDC should be taken without food by patients experiencing central nervous system toxicities. © 2012 Mohammed Lamorde et al.
Authors & Co-Authors
Lamorde, Mohammed
Uganda, Kampala
Makerere University
Ireland, Dublin
St James's Hospital
Byakika-Kibwika, Pauline
Uganda, Kampala
Makerere University
Ireland, Dublin
St James's Hospital
Uganda, Kampala
Infectious Diseases Network for Treatment and Research in Africa
Tamale, William S.
Uganda, Kampala
Joint Clinical Research Center Uganda
Kiweewa, Francis
Uganda, Kampala
Joint Clinical Research Center Uganda
Ryan, Máirín A.A.
Ireland, Dublin
St James's Hospital
Amara, Alieu B.
United Kingdom, Liverpool
University of Liverpool
Tjia, John F.
United Kingdom, Liverpool
University of Liverpool
Back, David J.
United Kingdom, Liverpool
University of Liverpool
Khoo, Saye Hock
United Kingdom, Liverpool
University of Liverpool
Boffito, Marta A.
United Kingdom, London
Chelsea and Westminster Hospital
Kityo, Cissy Mutuluuza
Uganda, Kampala
Joint Clinical Research Center Uganda
Merry, Concepta
Uganda, Kampala
Makerere University
Ireland, Dublin
St James's Hospital
Uganda, Kampala
Infectious Diseases Network for Treatment and Research in Africa
Statistics
Citations: 33
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1155/2012/105980
e-ISSN:
20901259
Research Areas
Food Security
Infectious Diseases