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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Parental consanguinity and family history of coronary artery disease strongly predict early stenosis
Atherosclerosis, Volume 212, No. 2, Year 2010
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Description
Background: Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim: We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in 4284 patients. The compounded impact of diabetes, hyperlipidemia, hypertension, smoking, and BMI, which are known CAD risk factors, on CAD risk and age at diagnosis was also explored. Methods: CAD was determined by cardiac catheterization. Logistic regression and stratification were performed to determine the impact of family history and consanguinity on risk and onset of CAD, controlling for diabetes, hyperlipidemia, hypertension, smoking, and BMI. Results: Family history of CAD and gender significantly increased the risk for young age at diagnosis of CAD (p< 0.001). Consanguinity did not promote risk of CAD (p= 0.38), but did affect age of disease diagnosis (p< 0.001). The mean age at disease diagnosis was lowest, 54.8 years, when both family history of CAD and consanguinity were considered as unique risk factors for CAD, compared to 62.8 years for the no-risk-factor patient category (p< 0.001). Conclusions: Family history of CAD and smoking are strongly associated with young age at diagnosis. Furthermore, parental consanguinity in the presence of family history lowers the age of disease diagnosis significantly for CAD, emphasizing the role of strong genetic and cultural CAD modifiers. These findings highlight the increased role of genetic determinants of CAD in some population subgroups, and suggest that populations and family structure influence genetic heterogeneity between patients with CAD. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Youhanna, Sonia C.
Lebanon, Beirut
Lebanese American University
Platt, Daniel E.
United States, Yorktown Heights
Ibm Thomas J. Watson Research Center
Rebeiz, Abdallah G.
Lebanon, Beirut
American University of Beirut
Lauridsen, Michael B.
Denmark, Bagsvard
Novo Nordisk A/s
Deeb, Mary E.
Lebanon, Beirut
Lebanese American University
Nasrallah, Antoine T.
Lebanon, Beirut
American University of Beirut
Alam, Samir E.
Lebanon, Beirut
American University of Beirut
Puzantian, Houry V.
Lebanon, Beirut
American University of Beirut
Kabbani, Samer
Lebanon, Beirut
Rafik Hariri University Hospital
Ghoul, Melanie
Lebanon, Beirut
American University of Beirut
Zreik, Tony G.
Lebanon, Beirut
Lebanese American University
el Bayeh, Hamid
Lebanon, Beirut
Lebanese American University
AbchÉE, Antoine B.
Lebanon, Beirut
American University of Beirut
Zalloua, Pierre A.
Lebanon, Beirut
Lebanese American University
United States, Boston
Harvard T.h. Chan School of Public Health
Gauguier, Dominique
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Lathrop, Mark G.
France, Evry
Centre National de Recherche en Génomique Humaine
Nicholson, Jeremy K.
United Kingdom, London
Imperial College London
Hager, Jörg
France, Evry
Integragen sa
Bonner, Frank
United Kingdom, London
Metabometrix Ltd
Statistics
Citations: 26
Authors: 19
Affiliations: 11
Identifiers
Doi:
10.1016/j.atherosclerosis.2010.07.013
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study