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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Viability of X-autosome translocations in mammals: An epigenomic hypothesis from a rodent case-study
Chromosoma, Volume 113, No. 1, Year 2004
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Description
X-autosome translocations are highly deleterious chromosomal rearrangements due to meiotic disruption, the effects of X-inactivation on the autosome, and the necessity of maintaining different replication timing patterns between the two segments. In spite of this, X-autosome translocations are not uncommon. We here focus on the genus Taterillus (Rodentia, Gerbillinae) which provides two sister lineages differing by two autosome-gonosome translocations. Despite the recent and dramatic chromosomal repatterning characterising these lineages, the X-autosome translocated species all display intercalary heterochromatic blocks (IHBs) between the autosomal and the ancestral sexual segments. These blocks, composed of highly amplified telomeric repeats and rDNA clusters, are not observed on the chromosomes of the non-translocated species, nor the Yl and Y2 of the translocated species. Such IHBs are found in all mammals documented for X-autosome translocation. We propose an epigenomic hypothesis which explains the viability of X-autosome translocations in mammals. This posits that constitutive heterochromatin is probably selected for in X-autosome translocations since it may (1) prevent facultative heterochromatinization of the inactivated X from spreading to the autosomal part, and (2) allow for the independent regulation of replication timing of the sex and autosomal segments. © Springer-Verlag 2004.
Authors & Co-Authors
Dobigny, Gauthier
France, Paris
Museum National D'histoire Naturelle
South Africa, Stellenbosch
Stellenbosch University
Ozouf-Costaz, Catherine
France, Paris
Museum National D'histoire Naturelle
Bonillo, Céline
France, Paris
Museum National D'histoire Naturelle
Volobouev, Vitaly T.
France, Paris
Museum National D'histoire Naturelle
Statistics
Citations: 69
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1007/s00412-004-0292-6
ISSN:
00095915
Research Areas
Sexual And Reproductive Health