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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Reductions in artemisinin-based combination therapy consumption after the nationwide scale up of routine malaria rapid diagnostic testing in Zambia
American Journal of Tropical Medicine and Hygiene, Volume 87, No. 3, Year 2012
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Description
The National Malaria Control Center of Zambia introduced rapid diagnostic tests (RDTs) to detect Plasmodium falciparum as a pilot in some districts in 2005 and 2006; scale up at a national level was achieved in 2009. Data on RDT use, drug consumption, and diagnostic results were collected in three Zambian health districts to determine the impact RDTs had on malaria case management over the period 2004-2009. Reductions were seen in malaria diagnosis and antimalarial drug prescription (66.1 treatments per facility-month (95% confidence interval [CI] = 44.7-87.4) versus 26.6 treatments per facility-month (95% CI = 11.8-41.4)) pre- and post-RDT introduction. Results varied between districts, with significant reductions in low transmission areas but none in high areas. Rapid diagnostic tests may contribute to rationalization of treatment of febrile illness and reduce antimalarial drug consumption in Africa; however, their impact may be greater in lower transmission areas. National scale data will be necessary to confirm these findings. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Yukich, Joshua O.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Bennett, Adam F.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Albertini, Audrey
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Incardona, Sandra
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Moonga, Hawela B.
Zambia, Lusaka
Zambian Ministry of Health
Chisha, Zunda
Zambia, Lusaka
Akros
Hamainza, Busiku
Zambia, Lusaka
Zambian Ministry of Health
Miller, John M.
Zambia, Lusaka
Zambian Ministry of Health
Keating, Joseph A.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Eisele, Thomas P.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Bell, David
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Statistics
Citations: 47
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2012.12-0127
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Zambia