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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD
European Respiratory Journal, Volume 47, No. 1, Year 2016
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Description
Purinergic receptor activation via extracellular ATP is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Nucleoside triphosphate diphosphohydrolase-1/CD39 hydrolyses extracellular ATP and modulates P2 receptor signalling. We aimed to investigate the expression and function of CD39 in the pathogenesis of cigarette smokeinduced lung inflammation in patients and preclinical mouse models. CD39 expression and soluble ATPase activity were quantified in sputum and bronchoalveolar lavage fluid (BALF) cells in nonsmokers, smokers and COPD patients or mice with cigarette smoke-induced lung inflammation. In mice, pulmonary ATP and cytokine concentrations, inflammation and emphysema were analysed in the presence or absence of CD39. Following acute cigarette smoke exposure CD39 was upregulated in BALF cells in smokers with further increases in COPD patients. Acute cigarette smoke exposure induced CD39 upregulation in murine lungs and BALF cells, and ATP degradation was accelerated in airway fluids. CD39 inhibition and deficiency led to augmented lung inflammation; treatment with ATPase during cigarette smoke exposure prevented emphysema. Pulmonary CD39 expression and activity are increased in COPD. CD39 deficiency leads to enhanced emphysema in mice, while external administration of a functional CD39 analogue partially rescues the phenotype. The compensatory upregulation of pulmonary CD39 might serve as a protective mechanism in cigarette smoke-induced lung damage. © ERS 2016.
Authors & Co-Authors
Lázár, Zsófia
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Hungary, Budapest
Semmelweis Egyetem
Kissné Horváth, Ildikó H.
Hungary, Budapest
Semmelweis Egyetem
Virchow, Johannes Christian
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Idzko, Marco
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Statistics
Citations: 25
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1183/13993003.02144-2014
ISSN:
09031936
Research Areas
Noncommunicable Diseases
Substance Abuse