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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The epidemiology and aetiology of infections in children admitted with clinical severe pneumonia to a university hospital in Rabat, Morocco
Journal of Tropical Pediatrics, Volume 60, No. 4, Article fmu010, Year 2014
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Description
Objectives: Scarce and limited epidemiological, clinical and microbiological data are available regarding paediatric respiratory tract infections in the Kingdom of Morocco, a middle-income country in northwestern Africa. The results of hospital-based surveillance aiming at describing the aetiology and epidemiology of respiratory distress among children <5 years of age are presented. Methods: Children admitted to the Hô pital d'Enfants de Rabat, Morocco, and meeting the World Health Organization clinical criteria for severe pneumonia were recruited over a period of 14 months and were thoroughly investigated to ascertain a definitive diagnosis. Results: In total, 700 children were recruited for the study. Most frequent clinical diagnoses included wheezing-related conditions (bronchitis/asthma, 46%; bronchiolitis, 15%), while typical bacterial pneumonia was infrequent (only 19% of the cases). Invasive bacterial disease detected by classical microbiology or molecular methods was also uncommon, affecting only 3.5% of the patients, and with an overall low detection of pneumococcal or Haemophilus influenzae type b disease. Conversely, coverage of respiratory viral detection in the nasopharynx was almost universal among cases (92%), with the three most frequent viruses detected being rhinovirus (53%), respiratory syncytial virus (18%) and adenovirus (17%). The overall case fatality rate (CFR) among recruited patients with a known outcome was 4.1% (28/690). Conclusions: In Morocco, the epidemiological profile of paediatric acute respiratory infections is markedly shifted towards wheezing-related diseases and thus resembles that of high-income countries. However, the high associated CFRs found in this study call for an improvement in preventive and clinical management strategies. © The Author [2014]. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Jroundi, Imane
Spain, Barcelona
Instituto de Salud Global de Barcelona
Morocco, Agdal Rabat
Ministry of Health, Morocco
Mahraoui, Chafiq
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Benmessaoud, Rachid
Spain, Barcelona
Instituto de Salud Global de Barcelona
Moraleda, Cinta
Spain, Barcelona
Instituto de Salud Global de Barcelona
Tligui, Houssain
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Seffar, Myriam
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Echcherif El Kettani, Salma
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Benjelloun, Badr Sououd D.
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Chaacho, Saad
Spain, Barcelona
Instituto de Salud Global de Barcelona
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Maaroufi, Abderrahmane
Morocco, Agdal Rabat
Ministry of Health, Morocco
Hayes, Edward B.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Álvarez-Martínez, Míriam José
Spain, Barcelona
Instituto de Salud Global de Barcelona
Muñoz-Almagro, Carmen
Spain, Esplugues de Llobregat
Hospital Sant Joan de Déu
Ruiz, Joaquim
Spain, Barcelona
Instituto de Salud Global de Barcelona
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Bassat, Quique
Spain, Barcelona
Instituto de Salud Global de Barcelona
Statistics
Citations: 34
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1093/tropej/fmu010
ISSN:
01426338
e-ISSN:
14653664
Research Areas
Health System And Policy
Maternal And Child Health
Study Locations
Morocco