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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2- thione derivatives: Promising anticancer agents
Bioorganic and Medicinal Chemistry, Volume 14, No. 4, Year 2006
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Description
A series of 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole- 2-thione derivatives was synthesized and 13 of them were selected by the National Cancer Institute (NCI) and evaluated for their in vitro anticancer activity. Seven of the investigated compounds, 3i, 3j, 3k, 3o, 3p, 3q, and 3r, displayed high anticancer activity in the primary assay. These compounds have been selected for a full anticancer screening against a 60-cell panel assay where they showed non-selective broad spectrum and promising activity against all cancer cell lines. Compounds 3j and 3k proved to be the active members in this study compared to 5-fluorouracil and cyclophosphamide as reference drugs, respectively. Compounds 3j and 3k were identified as promising lead compounds. © 2005 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Aboraia, Ahmed Safwat M.
Egypt, Asyut
Faculty of Pharmacy
Abdel-Rahman, Hamdy M.
Egypt, Asyut
Faculty of Pharmacy
Mahfouz, Nadia M.A.
Egypt, Asyut
Faculty of Pharmacy
El Gendy, Mohamed A.M.
Egypt, Asyut
Faculty of Pharmacy
Statistics
Citations: 198
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.bmc.2005.09.053
ISSN:
09680896
Research Areas
Cancer