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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genomic epidemiology of azithromycin-nonsusceptible neisseria gonorrhoeae, Argentina, 2005-2019
Emerging Infectious Diseases, Volume 27, No. 9, Year 2021
Notification
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Description
Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015-2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005-2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015-November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2-4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2-4 or ≥256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina. © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
Authors & Co-Authors
Golparian, Daniel
Switzerland, Geneva
Organisation Mondiale de la Santé
Unemo, Magnus
Switzerland, Geneva
Organisation Mondiale de la Santé
Campos, Josefina
Argentina, Buenos Aires
Administracion Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbran
Galarza, Patricia G.
Argentina, Buenos Aires
Administracion Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbran
Vilches, Viviana E.
Unknown Affiliation
Sparo, Mónica D.
Unknown Affiliation
Rizzo, Maria Fernanda
Unknown Affiliation
Basco, Leonardo K.
Unknown Affiliation
Statistics
Citations: 6
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.3201/eid2709.204843
ISSN:
10806040
Study Design
Cross Sectional Study