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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Report from a WHO Working Group: standard method for detecting upper respiratory carriage ofStreptococcus pneumoniae
Pediatric Infectious Disease Journal, Volume 22, No. 2, Year 2003
Notification
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Description
Background. Numerousstudies evaluating the efficacy of conjugate pneumococcal vaccines are being conducted or planned throughout the world. Some of these studies are evaluating the effect of vaccine on nasopharyngeal (NP) carriage. Methods. The World Health Organization established a Working Group comprised of representatives from these trials and other NP colonization experts to establish core, standardized methods for the study of pneumococcal NP colonization that could be used in these trials. The intent was to reduce or eliminate variability in key methods which themselves could contribute to variability of observed pneumococcal NP colonization. In this way variability of vaccine effects between trials on NP colonization could more easily be analyzed for population or vaccine differences without the confounding effect caused by differences in study methodology. Results. This paper presents the evidence base supporting the need for standardized NP colonization study methods, the methods themselves (Core Consensus Methods), including collection techniques, culture media, equipment, serotyping, storage of specimens and transport of isolates agreed on by the Working Group as well as a discussion of research priorities. Conclusions. The Core Consensus Methods provide a common methodology to conduct pneumococcal NP colonization studies with minimum interstudy method variability. The intention is to allow more meaningful comparisons of study results from conjugate pneumococcal vaccine trials. © 2003 Lippincott Williams and Wilkins, Inc.
Authors & Co-Authors
O'Brien, Katherine L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Denmark, Copenhagen
Statens Serum Insitut
United States, Atlanta
Rollins School of Public Health
South Africa, Johannesburg
National Health Laboratory Service
Australia, Darwin
Menzies School of Health Research
United States, Baltimore
University of Maryland, Baltimore Umb
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Baltimore
Johns Hopkins University
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Philippines, Manila
Research Institute for Tropical Medicine
United Kingdom, London
Imperial College London
Nohynek, Hanna M.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Cherian, Thomas
Australia, Melbourne
Royal Children's Hospital, Melbourne
Switzerland, Geneva
Organisation Mondiale de la Santé
Mulholland, Edward Kim
Australia, Melbourne
Royal Children's Hospital, Melbourne
Switzerland, Geneva
Organisation Mondiale de la Santé
Dagan, Ron
Israel, Beer Sheva
Soroka University Medical Center
Yagupsky, Pablo V.
Israel, Beer Sheva
Soroka University Medical Center
Gratten, Michael J.
Australia, Brisbane
Queensland Health
Statistics
Citations: 213
Authors: 8
Affiliations: 17
Identifiers
Doi:
10.1097/01.inf.0000049347.42983.77
ISSN:
08913668
e-ISSN:
15320987
Study Design
Cross Sectional Study