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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study
Movement Disorders, Volume 20, No. 9, Year 2005
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Description
Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study. © 2005 Movement Disorder Society.
Authors & Co-Authors
Suchowersky, Oksana
Canada, Calgary
University of Calgary
Guttman, Mark
Canada, Toronto
University of Toronto
Liu, Jianhua Liang
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
DeStefano, Anita L.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Latourelle, Jeanne C.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Watts, Ray L.
United States, Atlanta
Emory University
Waters, Cheryl H.
United States, Los Angeles
University of Southern California
Pramstaller, Peter P.
Italy, Bolzano
Regional Hospital of Bolzano
Klein, Christine
Germany, Lubeck
Universität zu Lübeck
Racette, Brad A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Perlmutter, Joel S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Gusella, James F.
United States, Boston
Harvard Medical School
Herbert, Alan G.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Myers, Richard H.M.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Statistics
Citations: 18
Authors: 14
Affiliations: 14
Identifiers
Doi:
10.1002/mds.20515
ISSN:
08853185
Research Areas
Genetics And Genomics