Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Advantage of carbonate- versus citrate-based alkalinization on bone metabolism in moderately exercising aged male rats fed an, acidogenic diet
Journal of Biological Regulators and Homeostatic Agents, Volume 25, No. 3, Year 2011
Notification
URL copied to clipboard!
Description
This study aims to determine the effects of different alkaline supplementations on high protein diet-induced abnormalities affecting bone metabolism in rats which were also undergoing physical exercise of moderate intensity. Sixty elderly Sprague-Dawley rats were randomly divided into four groups of 10 rats each and treated for 16 weeks as follows: baseline control group fed normal food (C); acidic high-protein diet supplemented group (chronic acidosis, CA group), bicarbonate-based alkaline formula (Basenpulver, Named, Italy) supplemented chronic acidosis (BB-CA) and citrate-based alkaline supplement (CB-CA). Throughout the supplementation period, rats were put on a treadmill training mimicking a moderate level of exercise. In the CA group, 24-hour urinary calcium (Ca) and phosphorus (P) excretion were increased over 30% (p<0.05 vs normal diet controls). However serum Ca was not significantly changed. Femural and tibial BMD and BMC was significantly decreased in the CA group (p<0.05) but both alkaline supplementations prevented such phenomenon (p<0.05 vs CA), without significant difference between the two formulations although the BB-CA group showed significantly more preserved trabecular bone volume (p<0.05 vs CB-CA group). An increased level of over 50% of urinary Dpd observed in the CA group (p<0.001) was reverted to normal by both supplementations (p<0.001 vs CA group). The same applied to urinary net acid excretion (p<001) with BB-supplementation performing better than CB-supplementation (p<0.05). Moreover, while the latter did not modify N-terminal telopeptide value, BB-supplementation significantly normalized this parameter (p<0.05 vs CA group) which exercise and acidic protein diet had modified (p<0.01 vs control diet). Overall, the present study shows that a bicarbonate-based alkaline formula, when administered to a dose amenable to clinical use, may significantly protect bone structure in exercising aged animals to a greater extent than a quali/quantitavely similar citrate-based formula. Copyright © by BIOLIFE, s.a.s.
Authors & Co-Authors
Sedriep, S.
Japan, Miyazaki
Bio-cell Unit Lab and Analysis Center
Zhong, K.
China, Beijing
Peking University
Nakanishi, K.
Japan, Miyazaki
Bio-cell Unit Lab and Analysis Center
Sweed, Hala S.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Chui, D. H.
China, Beijing
Peking University
Yang, H.
China, Beijing
Peking University
Xia, X.
China, Guilin
Guilin Medical College
Catanzaro, Roberto
Italy, Catania
Università Degli Studi Di Catania
Zhou, L.
China, Beijing
Peking University
Marotta, F.
Italy, Milan
Regenera Research Group for Aging Intervention
Statistics
Citations: 10
Authors: 10
Affiliations: 6
Identifiers
ISSN:
0393974X
Research Areas
Food Security
Study Design
Randomised Control Trial
Participants Gender
Male