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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Recurrent isolation of poliovirus 3 strains with chimeric capsid protein Vp1 suggests a recombination hot-spot site in Vp1
Virus Research, Volume 151, No. 2, Year 2010
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Description
Five oral poliovirus vaccine (OPV) strains carrying an intertypic PV3/PV2 recombination in VP1 capsid protein were isolated during poliovirus surveillance. These five PV3 strains had altogether four diverse recombination crossover points near the 3' end of the VP1 coding region. The complete antigenic site IIIa was replaced by PV2-specific amino acids in four of the studied PV3 strains. Low overall number of nucleotide substitutions in VP1 indicated that the predicted replication time, " age" , of the PV3 strains was short, 6 months or less. The nucleotide 472-T in the 5' non-coding region, associated to the attenuated phenotype of PV3/Sabin, was reverted to wild-type C in all studied PV3/PV2 recombinant strains. Three of the PV3 strains had at least a tripartite genome deduced from the partial 3D polymerase-coding region sequences. Our results suggest that there exists a PV3/PV2 recombination hot-spot site in the 3' partial region of the VP1 capsid protein and that the recombination may occur within weeks or a few months after the administration of OPV. © 2010 Elsevier B.V.
Authors & Co-Authors
Blomqvist, Soile
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Savolainen-Kopra, Carita
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Paananen, Anja
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
El Bassioni, Laila
Egypt, Cairo
The Egyptian Organization for Biological Products and Vaccines Egyvac-vacsera
El Maamoon Nasr, Eman M.
Egypt, Cairo
The Egyptian Organization for Biological Products and Vaccines Egyvac-vacsera
Firstova, Larisa
Latvia, Riga
Sports Medicine State Agency
Zamiatina, Natalia
Latvia, Riga
Sports Medicine State Agency
Kutateladze, Tamar
Georgia, Tbilisi
National Center for Disease Control and Public Health
Roivainen, Merja M.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Statistics
Citations: 19
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.virusres.2010.05.006
ISSN:
01681702
Research Areas
Health System And Policy