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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Selenium stimulates pancreatic beta-cell gene expression and enhances islet function
FEBS Letters, Volume 582, No. 15, Year 2008
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Description
The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the -2715 to -1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function. © 2008 Federation of European Biochemical Societies.
Authors & Co-Authors
Campbell, Susan C.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Aldibbiat, Ali
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Marriott, Claire E.
United Kingdom, Brighton
University of Brighton
Landy, Caroline
United Kingdom, Brighton
University of Brighton
Ali, Tomader
United Kingdom, Brighton
University of Brighton
Ferris, William Frank
South Africa, Stellenbosch
Stellenbosch University
Butler, Clive S.
United Kingdom, Exeter
University of Exeter
Shaw, James A.M.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Macfarlane, Wendy M.
United Kingdom, Brighton
University of Brighton
Statistics
Citations: 9
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.febslet.2008.05.038
ISSN:
00145793
Research Areas
Genetics And Genomics