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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
Journal of Virology, Volume 85, No. 21, Year 2011
Notification
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Description
A small proportion of HIV-infected individuals generate a neutralizing antibody (NAb) response of exceptional magnitude and breadth. A detailed analysis of the critical epitopes targeted by broadly neutralizing antibodies should help to define optimal targets for vaccine design. HIV-1-infected subjects with potent cross-reactive serum neutralizing antibodies were identified by assaying sera from 308 subjects against a multiclade panel of 12 "tier 2" viruses (4 each of subtypes A, B, and C). Various neutralizing epitope specificities were determined for the top 9 neutralizers, including clade A-, clade B-, clade C-, and clade A/C-infected donors, by using a comprehensive set of assays. In some subjects, neutralization breadth was mediated by two or more antibody specificities. Although antibodies to the gp41 membrane-proximal external region (MPER) were identified in some subjects, the subjects with the greatest neutralization breadth targeted gp120 epitopes, including the CD4 binding site, a glycan-containing quaternary epitope formed by the V2 and V3 loops, or an outer domain epitope containing a glycan at residue N332. The broadly reactive HIV-1 neutralization observed in some subjects is mediated by antibodies targeting several conserved regions on the HIV-1 envelope glycoprotein. © 2011, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3194956/bin/supp_85_21_11502__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3194956/bin/supp_85_21_11502__1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3194956/bin/supp_85_21_11502__2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3194956/bin/supp_85_21_11502__3.pdf
Authors & Co-Authors
Tomaras, Georgia D.
United States, Durham
Duke University Medical Center
Binley, James M.
United States, San Diego
Torrey Pines Institute for Molecular Studies
Gray, Elin Solomonovna
South Africa, Johannesburg
National Institute for Communicable Diseases
Crooks, Emma T.
United States, San Diego
Torrey Pines Institute for Molecular Studies
Osawa, Keiko
United States, San Diego
Torrey Pines Institute for Molecular Studies
Moore, Penny L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Tumba, Nancy L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Tong, Tommy
United States, San Diego
Torrey Pines Institute for Molecular Studies
Shen, Xiaoying X.
United States, San Diego
Torrey Pines Institute for Molecular Studies
Yates, Nicole L.
United States, Durham
Duke University Medical Center
Decker, Julie M.
United States, San Diego
Torrey Pines Institute for Molecular Studies
Wibmer, Constantinos Kurt
South Africa, Johannesburg
National Institute for Communicable Diseases
Gao, Feng
United States, Durham
Duke University Medical Center
Alam, S. Munir
United States, Durham
Duke University Medical Center
Easterbrook, Philippa Jane
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Abdool Karim, Salim S.
South Africa, Durban
University of Kwazulu-natal
Kamanga, Gift
Malawi, Lilongwe
Kamuzu Central Hospital
Crump, John A.
United States, Durham
Duke University Medical Center
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Shaw, George M.
United States, Birmingham
The University of Alabama at Birmingham
Mascola, John R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Haynes, Barton F.
United States, Durham
Duke University Medical Center
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Statistics
Citations: 192
Authors: 24
Affiliations: 10
Identifiers
Doi:
10.1128/JVI.05363-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases