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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury
European Heart Journal, Volume 26, No. 21, Year 2005
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Description
Aims: Intravascular inflammatory events during ischaemia/reperfusion injury following coronary angioplasty alter and denudate the endothelium of its natural anticoagulant heparan sulfate proteoglycan (HSPG) layer, contributing to myocardial tissue damage. We propose that locally targeted cytoprotection of ischaemic myocardium with the glycosaminoglycan analogue dextran sulfate (DXS, MW 5000) may protect damaged tissue from reperfusion injury by functional restoration of HSPG. Methods and results: In a closed chest porcine model of acute myocardial ischaemia/reperfusion injury (60 min ischaemia, 120 min reperfusion), DXS was administered intracoronarity into the area at risk 5 min prior to reperfusion. Despite similar areas at risk in both groups (39 ± 8% and 42 ± 9% of left ventricular mass), DXS significantly decreased myocardial infarct size from 61 ± 12% of the area at risk for vehicle controls to 39 ± 14%. Cardioprotection correlated with reduced cardiac enzyme release creatine kinase (CK-MB, troponin-I). DXS abrogated myocardial complement deposition and substantially decreased vascular expression of pro-coagulant tissue factor in ischaemic myocardium. DXS binding, detected using fluorescein-labelled agent, localized to ischaemically damaged blood vessels/myocardium and correlated with reduced vascular staining of HSPG. Conclusion: The significant cardioprotection obtained through targeted cytoprotection of ischaemic tissue prior to reperfusion in this model of acute myocardial infarction suggests a possible role for the local modulation of vascular inflammation by glycosaminoglycan analogues as a novel therapy to reduce reperfusion injury. © The European Society of Cardiology 2005. All rights reserved.
Authors & Co-Authors
Banz, Yara
Switzerland, Bern
University of Bern
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Meier, Pascal Pascal
Switzerland, Bern
Swiss Cardiovascular Center, University Hospital Bern
Csizmadia, Eva
United States, Boston
Beth Israel Deaconess Medical Center
Bovin, Nicolaï Vladimirovich
Russian Federation, Moscow
Russian Academy of Sciences
Rieben, Robert
Switzerland, Bern
University of Bern
Statistics
Citations: 37
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1093/eurheartj/ehi421
ISSN:
15229645
Research Areas
Noncommunicable Diseases
Violence And Injury