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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A fatal case of acute hepatitis e among pregnant women, Central African Republic
BMC Research Notes, Volume 3, Article 103, Year 2010
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Description
Background. Hepatitis E virus (HEV) is a major public health problem in developing countries. HEV infection in pregnant women is more common and more often fatal in the third trimester. The mortality rate due to HEV-induced hepatitis is as high as 15-20 per cent. The present study was designed to determine the potential factors responsible for high mortality rate among pregnant women. Findings. Twenty one pregnant women attended the Maternity Center of Begoua in the Central African Republic during an outbreak of hepatitis E virus between July and October 2002 with symptoms of acute liver disease. Their mean gestational period was 29.9 (SD 8.3 weeks) and they were aged from 15 to 39 years old. The serology IgM showed that seven women (33%) had acute hepatitis E. Among them, one woman, aged 35 and her newborn died after an apparently normal preterm delivery. The 6 remaining young women, age 18 - 22, had preterm deliveries which included three live babies and three stillborn with one macerated. Conclusions. These results suggest that maternal age, in addition to hormonal, immunological and environmental factors, may be a risk factor for fatal outcome. © 2010 Komas et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Goumba, Charles M.
Central African Republic
Service de Gynécologie-obstétrique
Nakouné, Emmanuel Rivalyn
Central African Republic, Bangui
Institut Pasteur de Bangui
Komas, Narcisse Patrice Joseph
Central African Republic, Bangui
Institut Pasteur de Bangui
Statistics
Citations: 40
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1186/1756-0500-3-103
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Central African Republic
Participants Gender
Female