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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma
World Journal of Gastroenterology, Volume 18, No. 15, Year 2012
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Description
AIM: To correlate cyclooxygenase-2 (COX-2) expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma (CRC). METHODS: Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with CRC. Patients were diagnosed and treated at the Departments of Surgery and Oncology, King Abdulaziz University Hospital, Saudi Arabia. RESULTS: Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression, whereas 44% of cases were completely COX-2-negative. There were no significant correlations between COX-2 expression and sex, age, grade or tumor location. However, COX-2 expression revealed a significant correlation with tumor stage (P = 0.01) and distant metastasis (P = 0.02), and a borderline association with lymph node involvement (P = 0.07). Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression (P < 0.009). In univariate Kaplan-Meier survival analysis, there was a significant (P = 0.026) difference in disease-free survival between COX-2-positive and negative tumors in favor of the latter. COX-2 expression did not significantly predict disease-specific survival, which was much shorter for COX-2-positive tumors. In multivariate (COX) models, COX-2 did not appear among the independent predictors of disease-free survival or disease-specific survival. CONCLUSION: COX-2 expression seems to provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease. © 2012 Baishideng. All rights reserved.
Authors & Co-Authors
Al-Maghrabi, Jaudah Ahmed
Saudi Arabia, Jeddah
King Abdulaziz University
Buhmeida, Abdelbaset
Saudi Arabia, Jeddah
King Abdulaziz University
Emam, Eman E.
Saudi Arabia, Jeddah
King Abdulaziz University
Syrjänen, Kari Juhani
Finland, Turku
Turun Yliopistollinen Keskussairaala
Sibiany, Abdul Rahman M.
Saudi Arabia, Jeddah
King Abdulaziz University
Al-Qahtani, Mohammed Hussain
Saudi Arabia, Jeddah
King Abdulaziz University
Al-Ahwal, Mahmoud Shaheen
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 39
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.3748/wjg.v18.i15.1793
ISSN:
10079327
Research Areas
Cancer
Health System And Policy