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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic diversity of hepatitis B virus (HBV) in Madagascar
Journal of Medical Virology, Volume 88, No. 12, Year 2016
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Description
Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family. Chronic infection with HBV is one major risk factor of hepatic disease. In Madagascar, former studies classified the country as part of high endemic area, as HBV prevalence can reach 23% in general population. However, this prevalence differs largely between urban and rural areas and is estimated to be, respectively, 5% and 26%. The aims of the present study were to describe the genetic diversity of HBV strains from different regions of Madagascar, and to describe the viral gene flow throughout the country by using phylogenetic analysis. This is the first large-scale molecular and phylogenetic study analyzing HBV sequences from 28 different Malagasy areas, never sampled in the past. In this study, the most prevalent genotype/sub-genotypes was E. Migration analysis showed a gene flow from zone 3 (rural) to zone 2 (suburban), and a greater gene flow from the middle part of Madagascar to the north than to the south. It is important to study the HBV infections in Madagascar and to monitor the potential spread of this viral strain inside this country. J. Med. Virol. 88:2138–2144, 2016. © 2016 Wiley Periodicals, Inc.
Authors & Co-Authors
Andriamandimby, Soa Fy
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Lo Presti, Alessandra
Italy, Rome
Istituto Superiore Di Sanita
Lai, Alessia
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Olive, Marie Marie
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Angeletti, Silvia
Italy, Rome
University Hospital Campus Bio-medico
De Florio, Lucia
Italy, Rome
University Hospital Campus Bio-medico
Cella, Eleonora
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
Sapienza Università Di Roma
Razafindramparany, Minoharimbola
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ravalohery, Jean Pierre
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Andriamamonjy, Seta
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Gioffrè, Sonia
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Zehender, Gianguglielmo
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Mottini, Giovanni
Italy, Rome
University Hospital Campus Bio-medico
Ciccozzi, M.
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
University Hospital Campus Bio-medico
Héraud, Jean Michel
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 15
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.24576
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Madagascar