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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behçet's disease in Tunisians
Joint Bone Spine, Volume 79, No. 2, Year 2012
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Description
Objectives: Reports of immunomodulating effects of vitamin D suggest a need for examining allele and genotype frequencies of the vitamin D nuclear receptor gene (VDR) in patients with autoimmune diseases. T-helper-1 (Th1) counts in peripheral blood are increased in both rheumatoid arthritis (RA) and Behçet's disease (BD). We studied VDR polymorphisms in patients with these two diseases in Tunisia. Methods: In 108 patients with RA, 131 patients with BD, and 152 controls, we studied FokI and BsmI VDR polymorphisms, using the restriction fragment length polymorphism technique. Results: The FokI polymorphism alleles and genotype were significantly more common in the RA group than in the controls (P= 0.001 and P= 0.005, respectively). The FokI F allele and F/F genotype were significantly associated with BD (P= 0.0003 and P= 0.002, respectively). Furthermore, in the group with BD, the FokI polymorphism was significantly associated with the presence of vascular manifestations (P= 0.006). In patients with RA, the FokI polymorphism was significantly associated with female gender (P= 0.003). No significant associations were found between the Bsm1 polymorphism and RA or BD. Conclusion: The VDR F allele is associated with RA and BD in Tunisians. © 2011 Société française de rhumatologie.
Authors & Co-Authors
Karray, Emna Fakhfakh
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, La Marsa
Université de Tunis el Manar, Hôpital Mongi Slim
Ben Dhifallah, Imen
Tunisia, Tunis
Faculté de Médecine de Tunis
Ben Abdelghani, Kaouther
Tunisia, La Marsa
Université de Tunis el Manar, Hôpital Mongi Slim
Ben Ghorbel, Imed
Tunisia, Tunis
Hôpital la Rabta
Khanfir, Monia Smiti
Tunisia, Tunis
Hôpital la Rabta
Houman, Mohammed Habib
Tunisia, Tunis
Hôpital la Rabta
Hamzaoui, Kamel
Tunisia, Tunis
Faculté de Médecine de Tunis
Zakraoui, Leïth
Tunisia, La Marsa
Université de Tunis el Manar, Hôpital Mongi Slim
Statistics
Citations: 76
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jbspin.2011.06.003
ISSN:
1297319X
e-ISSN:
17787254
Research Areas
Cancer
Genetics And Genomics
Study Locations
Tunisia
Participants Gender
Female