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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Autosomal dominant inheritance of central centrifugal cicatricial alopecia in black South Africans
Journal of the American Academy of Dermatology, Volume 70, No. 4, Year 2014
Notification
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Description
Background: Central centrifugal cicatricial alopecia (CCCA) is the commonest type of primary scarring alopecia in women of African descent. Little is currently known about the disease genetics. Objective: We sought to investigate patterns of inheritance in CCCA and ascertain the contribution of nongenetic factors such as hair-grooming habits to the pathogenesis of the disease. Methods: Affected individuals with at least 1 available family member were recruited from 2005 through 2012 inclusive for pedigree analysis. CCCA was diagnosed on clinical and histopathological grounds. Results: Fourteen index African families with 31 immediate family members participated in the initial screening. The female to male ratio was 29:2 with an average age of 50.4 years. All patients displayed histologic features typical for CCCA. Pedigree analysis suggested an autosomal dominant mode of inheritance. Hair-grooming habits were found to markedly influence disease expression. Limitations: Small number of patients is a limitation. Conclusion: CCCA can be inherited in an autosomal dominant fashion, with partial penetrance and a strong modifying effect of hairstyling and gender. © 2014 by the American Academy of Dermatology, Inc.
Authors & Co-Authors
Dlova, Ncoza Cordelia
South Africa, Durban
The Nelson R. Mandela Medical School
Jordaan, Francois H.
South Africa, Stellenbosch
Stellenbosch University
Sarig, Ofer
Israel, Tel Aviv-yafo
Tel Aviv Sourasky Medical Center
Sprecher, Eli
Israel, Tel Aviv-yafo
Tel Aviv Sourasky Medical Center
Israel, Tel Aviv-yafo
Tel Aviv University
Statistics
Citations: 48
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.jaad.2013.11.035
ISSN:
01909622
e-ISSN:
10976787
Research Areas
Genetics And Genomics
Participants Gender
Male
Female