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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antiretroviral therapy in prevention of HIV and TB: Update on current research efforts
Current HIV Research, Volume 9, No. 6, Year 2011
Notification
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Description
There is considerable scientific evidence supporting the use of antiretroviral therapy (ART) in prevention of human immunodeficiency virus (HIV) and tuberculosis (TB) infections. The complex nature of the HIV and TB prevention responses, resource constraints, remaining questions about cost and feasibility, and the need to use a solid evidence base to make policy decisions, and the implementation challenges to translating trial data to operational settings require a well-organised and coordinated response to research in this area. To this end, we aimed to catalogue the ongoing and planned research activities that evaluate the impact of ART plus other interventions on HIV- and/or TB-related morbidity, mortality, risk behaviour, HIV incidence and transmission. Using a limited search methodology, 50 projects were identified examining ART as prevention, representing 5 regions and 52 countries with a global distribution. There are 24 randomised controlled clinical trials with at least 12 large randomised individual or community cluster trials in resource-constrained settings that are in the planning or early implementation stages. There is considerable heterogeneity between studies in terms of methodology, interventions and geographical location. While the identified studies will undoubtedly advance our understanding of the efficacy and effectiveness of ART for prevention, some key questions may remain unanswered or only partially answered. The large number and wide variety of research projects emphasise the importance of this research issue and clearly demonstrate the potential for synergies, partnerships and coordination across funding agencies. © 2011 Bentham Science Publishers.
Authors & Co-Authors
Granich, Reuben M.
Unknown Affiliation
Gupta, Somya
Unknown Affiliation
Suthar, Amitabh Bipin
Unknown Affiliation
Smyth, Caoimhe
Unknown Affiliation
Hoos, David
Unknown Affiliation
Vitória, Marco Antônio De Ávila
Unknown Affiliation
Simao, Mariangela
Unknown Affiliation
Hankins, Catherine
Unknown Affiliation
Schwärtlander, Bernhard
Unknown Affiliation
Ridzon, Renée
Unknown Affiliation
Bazin, Brigitte
Unknown Affiliation
Williams, Brian Gerard
Unknown Affiliation
Lo, Ying Ru Jacqueline
Unknown Affiliation
McClure, Craig M.
Unknown Affiliation
Montaner, Julio S.G.
Unknown Affiliation
Hirnschall, Gottfried O.
Unknown Affiliation
Statistics
Citations: 95
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.2174/157016211798038597
ISSN:
1570162X
e-ISSN:
18734251
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study