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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association of Budd-Chiari syndrome and celiac disease
Gastroenterologie Clinique et Biologique, Volume 34, No. 11, Year 2010
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Description
Background and aims: An association between Budd-Chiari syndrome (BCS) and celiac disease (CD) is uncommon. The aims of our study were to investigate the etiology of BCS and to search for a particular HLA Ag pattern among patients. Patients and methods: BCS diagnosis was based on Doppler ultrasound and CD diagnosis on duodenal biopsy, transglutaminase (TGAb) and gliadin antibodies (GAb). Patients were screened for prothrombotic disorders and seven had a PCR-SSO test for HLA genotypes. Patients were treated with anticoagulants and gluten-free diet. Results: Nine patients were included; mean age 27 years (20-42); sex ratio (F/M) 2; mean follow-up duration 31 months (6-54). All patients had endoscopic and histological features of CD. GAb/TGAb were found in 78 % (n=7). Ag HLA found were HLA DQβ1*02 (n=6) and DQβ1*03 (n=3). Prothrombotic conditions identified were latent myeloproliferative disorder (n=1), protein C deficiency (n=1), probable factor V Leiden (n=1) and oral contraceptive use (n=1). No prothrombotic state could be identified in the five other patients. Conclusion: The BCS-CD association is relatively frequent in our country. Underlying prothrombotic conditions were absent in more than 50 % of cases, suggesting CD plays a role in the occurrence of thrombosis. HLA alleles found are strongly associated with CD, without any particular pattern for the BCS-CD association. © 2010 Elsevier Masson SAS.
Authors & Co-Authors
Afredj, Nawel
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Metatla, S.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Faraoun, Sid Ahmed
Algeria, Algiers
Centre Pierre et Marie Curie
Nani, Abdelbasset
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Guessab, Nawal
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Benhalima, M.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Bendib, Salah Eddine
Algeria, Algiers
Centre Pierre et Marie Curie
Debzi, Nabil
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Layaida, Karim
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Gamar, L.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Baiod, N.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Balamane, M.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Kaddache, N.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Bounab, N.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Kecili, L.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Boucekkine, Tadjeddine E.
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Statistics
Citations: 16
Authors: 16
Affiliations: 2
Identifiers
Doi:
10.1016/j.gcb.2010.07.007
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Cohort Study