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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania
Journal of Infectious Diseases, Volume 195, No. 4, Year 2007
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Description
We assessed the influence that consecutive-day blood sampling, compared with single-day blood sampling, had on polymerase chain reaction (PCR)-adjusted parasitological cure after stepwise genotyping of merozoite surface proteins 2 (msp2) and 1 (msp1) in 106 children in Tanzania who had uncomplicated falciparum malaria treated with either sulfadoxine-pyrimethamine or artemether- lumefantrine; 78 of these children developed recurrent parasitemia during the 42-day follow-up period. Initial msp2 genotyping identified 27 and 33 recrudescences by use of single- and consecutive-day sampling, respectively; in subsequent msp1 genotyping, 17 and 21 of these episodes, respectively, were still classified as recrudescences; these results indicate a similar sensitivity of the standard single-day PCR protocol - that is, 82% (27/33) and 81% (17/21), in both genotyping steps. Interpretation of PCR-adjusted results will significantly depend on methodology. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Mårtensson, Andreas A.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Katrineholm
Kullbergska Hospital
Ngasala, Billy E.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Ursing, Johan
Sweden, Stockholm
Karolinska Universitetssjukhuset
Veiga, Maria Isabel
Sweden, Stockholm
Karolinska Universitetssjukhuset
Portugal, Faro
Universidade do Algarve
Wiklund, Lisa
Sweden, Stockholm
Karolinska Universitetssjukhuset
Membi, Christopher D.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Montgomery, Scott M.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Orebro
Universitetssjukhuset Örebro
Premji, Zulfiqarali G.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Färnert, Anna
Sweden, Stockholm
Karolinska Universitetssjukhuset
Bjǒrkman, Anders B.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 60
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1086/510910
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Tanzania