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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genomic modulators of gene expression in human neutrophils
Nature Communications, Volume 6, Article 7545, Year 2015
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Description
Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil function, with 450 of these not previously observed in myeloid or lymphoid cells. Paired comparison with monocyte eQTL demonstrates nuanced conditioning of genetic regulation of gene expression by cellular context, which relates to cell-type-specific DNA methylation and histone modifications. Neutrophil eQTL are markedly enriched for trait-associated variants particularly autoimmune, allergy and infectious disease. We further demonstrate how eQTL in PADI4 and NOD2 delineate risk variant function in rheumatoid arthritis, leprosy and Crohn's disease. Taken together, these data help advance understanding of the genetics of gene expression, neutrophil biology and immune-related diseases. © 2015, Nature Publishing Group. All rights reserved.
Authors & Co-Authors
Naranbhai, Vivek
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Fairfax, Benjamin Peter
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Humburg, Peter
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hill, Adrian V. S.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Knight, Julian C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 95
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1038/ncomms8545
ISSN:
20411723
Research Areas
Genetics And Genomics
Study Approach
Quantitative