Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of the effect of oxidative stress and vitamin E supplementation on renal function in rats with streptozotocin-induced Type 1 diabetes
Journal of Diabetes and its Complications, Volume 23, No. 2, Year 2009
Notification
URL copied to clipboard!
Description
We investigated the possible role of reactive oxygen species (ROS) on renal function in experimental diabetes. Materials and Methods: Seven groups of male rats were studied. Group I consisted of control animals. Diabetes was induced (by streptozotocin) in the animals in the other groups and they received either insulin or vitamin E (300 or 600 mg/kg), both insulin and vitamin E, or no treatment for 4 weeks. At the end of the study, blood pressure was measured and parameters of kidney function and oxidative stress were evaluated in serum and kidney tissue samples. Results: Diabetic animals had higher blood pressures; increased serum glucose, urea, creatinine, cyclic guanosine monophosphate (cGMP); increased kidney tissue levels of malondialdehyde and inducible nitric oxide synthetase (iNOS); and reduced serum glutathione peroxidase when compared with control animals. Blood glucose levels in diabetic animals were controlled by insulin and not by any dose of vitamin E alone. However, all other measured parameters improved towards control levels with either insulin or vitamin E in either dose. An additive beneficial effect was observed on the levels of iNOS and cGMP when both forms of treatment were used in diabetic animals. Conclusions: We conclude that ROS may play an important role in diabetes-induced nephropathy in this rat model. Vitamin E supplementation in addition to insulin can have additive protective effects against deterioration of renal function in this model. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Haidara, M. A.
Egypt, Cairo
Faculty of Medicine
Mikhailidis, D. P.
United Kingdom, London
The Royal Free Hospital
United Kingdom, London
Ucl Medical School
Rateb, Moshira
Egypt, Cairo
Faculty of Medicine
Ahmed, Zeinab A.
Egypt, Cairo
Faculty of Medicine
Yassin, Hanaa Zaki
Egypt, Cairo
Faculty of Medicine
Ibrahim, Ibrahim M.
Egypt, Cairo
Faculty of Medicine
Rashed, Laila Ahmed
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 121
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.jdiacomp.2008.02.011
ISSN:
10568727
Research Areas
Noncommunicable Diseases
Participants Gender
Male