Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diffusion and perfusion MR imagine in cerebral lymphomas
Journal of Neuroradiology, Volume 33, No. 4, Year 2006
Notification
URL copied to clipboard!
Description
Because of the increasing incidence of cerebral lymphoma, it is critical for patient management to recognize the MR features of this disease. We present the characteristic morphological and functional MRI features of this tumor. The findings on MRI studies, including morphological, diffusion and perfusion imaging, performed in 9 biopsy-proven cases of cerebral lymphoma with 13 lesions are presented and analyzed, and are discussed in comparison with published literature data. All patients underwent diffusion-weighted imaging with a single shot echo-planar pulse sequence. Dynamic susceptibility-contrast MRI was performed using a T2*-weighted gradient-echo echo-planar sequence after intravenous injection of chelates of gadolinium at the rate of 6 ml/s and a temporal resolution of 1 second. All cases of cerebral lymphoma appeared hypointense or isointense on T1-weighted images and in 75% of cases iso- or hypointense on T2-weighted images. All lesions enhanced except one in a patient receiving steroid therapy. On diffusion-weighted images, tumours were hyperintense with normal or decreased ADC values (0.717±0.152.10 -3 mm2/sec, range: 0.550-1.014) and an ADC ratio tumour/normal white matter of 0.974±0.190 (range: 0.768-1.410). On perfusion, the signal intensity-time curve of each tumour showed a characteristic type of curve with a significant increase of the signal intensity above the baseline and a low maximum relative cerebral blood volume ratio (rCVBmax) of 1.43±0.64 (0.55-2.62). Due to their higher cellularity, the lack of neoangiogenesis, and the increased permeability of the blood-brain barrier related, to the infiltration of blood vessels wall by lymphomatous cells, cerebral lymphoma presents characteristic diffusion and perfusion MRI features that should be useful for diagnosis and patient follow-up. © 2006. Elsevier Masson SAS.
Authors & Co-Authors
Cotton, François
France, Lyon
Centre Hospitalier Lyon-sud
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Villeurbanne
Creatis Centre de Recherche en Acquisition et Traitement de L'image Pour la Santé
Ongolo-Zogo, Pierre
Cameroon, Yaounde
Université de Yaoundé I
Louis-Tisserand, Guy
France, Villeurbanne
Université Claude Bernard Lyon 1
Streichenberger, Nathalie
France, Villeurbanne
Université Claude Bernard Lyon 1
Hermier, Marc R.
France, Villeurbanne
Creatis Centre de Recherche en Acquisition et Traitement de L'image Pour la Santé
France, Villeurbanne
Université Claude Bernard Lyon 1
Jouvet, Anne
France, Villeurbanne
Université Claude Bernard Lyon 1
Hlaihel, Chadi
France, Lyon
Centre Hospitalier Lyon-sud
Jouanneau, Em̀manuel
France, Lyon
Hopital Neurologique et Neurochirurgical Pierre Wertheimer
Salles, Gilles André
France, Lyon
Centre Hospitalier Lyon-sud
Froment, Jean Claude
France, Villeurbanne
Creatis Centre de Recherche en Acquisition et Traitement de L'image Pour la Santé
France, Villeurbanne
Université Claude Bernard Lyon 1
Statistics
Citations: 42
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/s0150-9861(06)77267-4
ISSN:
01509861
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study