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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The use of TachoSil in children undergoing liver resection with or without segmental liver transplantation
European Journal of Pediatric Surgery, Volume 21, No. 2, Year 2011
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Description
Introduction: Local haemostatic agents are used for the control of surgical haemorrhage when standard techniques are inadequate, but there are few studies of these products in children. Patients and Methods: This was a prospective, open-label study in which children (aged 4 weeks to 6 years) undergoing liver resection with or without segmental liver transplantation were treated with TachoSil, a collagen patch coated with a dry layer of human fibrinogen and human thrombin, if minor (i. e., oozing) or moderate bleeding was present after primary haemostatic treatment. Time to haemostasis after TachoSil application was the primary endpoint. Safety was assessed by adverse events (AEs), including post-operative infections, symptoms of graft rejection and re-operations. Results: Enrolment was stopped early after 16 children had entered the study. 13 children underwent whole liver resection and transplantation and 3 patients underwent segmental resection. Satisfactory haemostasis was achieved in 13 children (81.3%; 95% CI: 61.8-100%) at 3 min and in 1 child at 8 min. Occurrence of AEs was as expected, with most being known complications of the underlying disease, surgical procedure, or use of immunosuppressive medication. No AEs were considered to be related to the use of TachoSil. Conclusions: The use of TachoSil for haemostasis after primary haemostatic treatment appears to be safe and effective in children undergoing liver resection. © Georg Thieme Verlag KG Stuttgart. New York.
Authors & Co-Authors
Mirza, Darius Feroze
United Kingdom, Birmingham
Birmingham Children's Hospital
Millar, Allistair John Ward
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Sharif, Khalid
United Kingdom, Birmingham
Birmingham Children's Hospital
Vilca-Meléndez, Hector
United Kingdom, London
King's College Hospital
Rela, Mohamed S.
United Kingdom, London
King's College Hospital
Heaton, Nigel
United Kingdom, London
King's College Hospital
Statistics
Citations: 13
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1055/s-0030-1267221
ISSN:
09397248
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study