Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
Organic and Biomolecular Chemistry, Volume 16, No. 1, Year 2017
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DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.