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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Symptomatic and functional outcome of bipolar disorder in Butajira, Ethiopia
Journal of Affective Disorders, Volume 90, No. 2-3, Year 2006
Notification
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Description
Background: Limited information is available on the outcome of bipolar disorder in developing countries. Objective: To describe the symptomatic and functional outcome of bipolar disorder. Methods: The psychoses and affective disorder modules of the CIDI were used to screen 68,378 individuals by a door-to-door survey of a defined district in Ethiopia. In addition, key informants were used to identify individuals with probable major mental illnesses. SCAN interviews were completed at the second stage to confirm the diagnosis. A total of 315 cases of bipolar disorder were identified, of which 264 (69 recent-onset and 195 prevalent cases) were prospectively followed for a mean of 2.5 (range 1-4) years by baseline and annual clinical assessments using symptom rating scales. Functional dimensions of the SF-36 scale were used to describe functional outcome. Random coefficient analyses were used to evaluate potential correlates of outcome. Results: The magnitudes of mania and depression symptoms were elevated at baseline but improved with follow-up, although the improvement was less marked for depression. Sociodemographic or clinical variables were not associated with the improvements in symptomatic outcome. Between 35% and 47% of the recent-onset cases had functional role restrictions, while 42-52% of long-standing cases had such restrictions during the follow-up years. Similarly, social and physical functioning deficits were also present in 52-86% and 35-47% of recent-onset and long-standing cases, respectively. The magnitude of depression and mania symptoms was associated with poor functional outcome, while male sex, rural residence and being married were associated with better functional outcome. Conclusion: Although there were improvements in function with follow-up, between one-third and one-half of cases continued to have functional deficits. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kebede, Derege
Zimbabwe, Harare
Greystone Park
Switzerland, Geneva
Organisation Mondiale de la Santé
Alem, Atalay
Zimbabwe, Harare
Greystone Park
Shibire, Teshome
Zimbabwe, Harare
Greystone Park
Deyessa, Negussie
Zimbabwe, Harare
Greystone Park
Negash, Alemayehu
Zimbabwe, Harare
Greystone Park
Beyero, Teferra
Zimbabwe, Harare
Greystone Park
Medhin, Girmay
Zimbabwe, Harare
Greystone Park
Fekadu, A.
Zimbabwe, Harare
Greystone Park
Statistics
Citations: 53
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.jad.2005.11.009
ISSN:
01650327
Research Areas
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Ethiopia
Participants Gender
Male