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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endometrial histopathology in patients with laparoscopic proven salpingitis and HIV-1 infection
Infectious Diseases in Obstetrics and Gynecology, Volume 2011, Article 407057, Year 2011
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Description
Study Objective. To identify sensitive and specific histological criteria for endometritis in women with laparoscopically-confirmed acute salpingitis. Methods. Women, age 18-40 years of age presenting with complaints of lower abdominal pain ≤2 weeks and no antibiotics use in past two weeks, were enrolled. They underwent clinical examination, screening for HIV; other sexually transmitted infections plus endometrial biopsy sampling for histopathology. Diagnostic laparoscopy confirmed the diagnosis of acute salpingitis. Controls were women undergoing tubal ligation and HIV-1 infected women asymptomatic for genital tract infection. Results. Of 125 women with laparoscopically-confirmed salpingitis, 38% were HIV-1 seropositive. Nineteen HIV-1 negative controls were recruited. For the diagnosis of endometritis, ≥1 plasma cells (PC) and ≥3 polymorphonuclear lymphocytes (PMN) per HPF in the endometrium had a sensitivity of 74 for HIV-1-seropositive, 63 for HIV-1-seronegative women with a specificity of 75 and positive predictive value of 85 regardless of HIV-1-infection for predicting moderate to severe salpingitis. For HIV-1-seronegative women with mild salpingitis, ≥1 PC and ≥3 PMN had a sensitivity of 16 and a PPV of 57. Conclusion. Endometrial histology, did not perform well as a surrogate marker for moderate to severe salpingitis, and failed as a surrogate marker for mild salpingitis. Copyright © 2011 Nelly R. Mugo et al.
Authors & Co-Authors
Mugo, Nelly Rwamba
Kenya, Nairobi
Kenyatta National Hospital
Kiehlbauch, Julia A.
Kenya, Nairobi
Kenya Medical Research Institute
United States, Seattle
Harborview Medical Center
United States, Baltimore
Dhmh
Kiviat, Nancy B.
United States, Seattle
Harborview Medical Center
Nguti, Rosemary
Kenya, Nairobi
University of Nairobi
Gichuhi, Joseph Wanyoike
Kenya, Nairobi
Kenyatta National Hospital
Kenya, Nairobi
University of Nairobi
Stamm, Walter E.
United States, Seattle
University of Washington
Cohen, Craig R.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 7
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1155/2011/407057
ISSN:
10647449
e-ISSN:
10980997
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female