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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii
Bioorganic and Medicinal Chemistry, Volume 21, No. 13, Year 2013
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Description
The addition of a DNA methyltransferase inhibitor, 5-azacytidine, to Aspergillus sydowii fungus culture broth changed its secondary metabolites profile. Analysis of the culture broth extract led to the isolation of three new bisabolane-type sesquiterpenoids: (7S)-(+)-7-O-methylsydonol (1), (7S,11S)-(+)-12-hydroxysydonic acid (2) and 7-deoxy-7,14-didehydrosydonol (3), along with eight known compounds. The isolated compounds were evaluated for their anti-diabetic and anti-inflammatory activities. Among the isolates, (S)-(+)-sydonol (4) did not only potentiate insulin-stimulated glucose consumption but also prevented lipid accumulation in 3T3-L1 adipocytes. Additionally, (S)-(+)-sydonol (4) exhibited significant anti-inflammatory activity through inhibiting superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils. This is the first report on isolating a secondary metabolite with anti-diabetic and anti-inflammatory activities from microorganisms. © 2013 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Chung, Yuming
Taiwan, Kaohsiung
Kaohsiung Medical University
Wei, Chien Kei
Taiwan, Kaohsiung
Kaohsiung Medical University
Chuang, Dawei
Taiwan, Kaohsiung
Kaohsiung Medical University
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Hsieh, Chiting
Taiwan, Kaohsiung
Kaohsiung Medical University
Asai, Teigo
Japan, Sendai
Tohoku University
Oshima, Yoshiteru
Japan, Sendai
Tohoku University
Hsieh, Tusty Jiuan
Taiwan, Kaohsiung
College of Medicine
Hwang, Tsong Long
Taiwan, Taoyuan
Chang Gung University College of Medicine
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Taichung
China Medical University
Taiwan, Taichung
China Medical University Hospital
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Statistics
Citations: 91
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.bmc.2013.04.004
ISSN:
09680896
e-ISSN:
14643391
Research Areas
Genetics And Genomics