Modeling of the elaborated hydroxyapatite synthesis from calcium carbonate and phosphoric acid solution

The elaboration of the phosphocalcic hydroxyapatite by precipitation from, a calcium carbonate solution and a phosphoric acid solution was conditioned by many factors such as the pH of reactional medium, the Ca/P molar ratio of the reagents, reaction time, and the initial concentration of calcium. The physicochemical properties of this hydroxyapatite thus prepared will be modified if these factors not have been chosen. In order to control these factors and thier effect on the synthesis of the phosphocalcic hydroxyaptite, we modeled the preparation of this product following a methodological strategy defining a plan of experiments. The mathematical model established, using a centered composite design, describes the change of the measured response of Ca/P molar ratio of the solid according to the pH of reactional medium, the Ca/P molar ratio of the reagents, and the initial concentration of calcium and the reaction time. The experimentals conditions have been optimized by this model. The product obtained is characterized by chemical analysis, X-ray diffraction (XR), and infrared Spectrometry (IR). Copyright © Taylor & Francis Group, LLC.