Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness
Antimicrobial Agents and Chemotherapy, Volume 58, No. 8, Year 2014
Notification
URL copied to clipboard!
Description
African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue of DB829, is the second simple diamidine found to cure mice with central nervous system infections by a parenteral route of administration. 28DAP010 showed efficacy similar to that of DB829 in dose-response studies in mouse models of first- and second-stage African sleeping sickness. The in vitro time to kill, determined by microcalorimetry, and the parasite clearance time in mice were shorter for 28DAP010 than for DB829. No cross-resistance was observed between 28DAP010 and pentamidine on the tested Trypanosoma brucei gambiense isolates from melarsoprol-refractory patients. 28DAP010 is the second promising preclinical candidate among the diamidines for the treatment of second-stage African sleeping sickness. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4136055/bin/supp_58_8_4452__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4136055/bin/AAC.02309-13_zac008143113so1.pdf
Authors & Co-Authors
Wenzler, Tanja
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Yang, Sihyung
United States, Lawrence
University of Kansas School of Pharmacy
Patrick, Donald A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Braissant, Olivier
Switzerland, Basel
Universitat Basel
Switzerland, Basel
Universitätsspital Basel
Ismail, Mohamed A.
United States, Atlanta
Georgia State University
Tidwell, Richard R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Boykin, David Withers
United States, Atlanta
Georgia State University
Wang, Michael Zhuo
United States, Lawrence
University of Kansas School of Pharmacy
Statistics
Citations: 20
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1128/AAC.02309-13
ISSN:
00664804