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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Volume 34, No. 5, Year 2022
Notification
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Description
Evidence for a relationship between polysubstance use, depression, and adherence to antiretroviral therapy (ART) is limited. The objectives of this study were to examine the associations of depression, illicit drug, and alcohol use with adherence to ART. People living with HIV (PLHIV) from the Miami Adult Studies on HIV cohort were asked about the number of doses of their ART medication missed to assess ART adherence. Harmful alcohol drinking was evaluated using the Alcohol Use Disorders Identification Test and illicit substance use assessed with self-report and urine screen. The Center for Epidemiologic Studies Depression Scale was used to assess depression symptoms. Of 391 PLHIV, 16.6% missed at least one dose (range:1–4) in the past four days. Cocaine/crack, opiate use, and depression were significantly independently associated with a greater mean number of doses missed. The mean number of doses missed was significantly greater among participants who used alcohol in combination with cocaine/crack, marijuana, and tobacco compared to non-users. In conclusion, polysubstance use increased the risk for poor ART adherence among PLHIV. The use of cocaine/crack or opiates individually and depressive symptoms also promote poor ART adherence. An integrated approach targeting substance disorders and depression may help achieve better ART adherence. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Authors & Co-Authors
Degarege, Abraham
United States, Omaha
University of Nebraska Medical Center
Krupp, Karl F.
United States, Tucson
The University of Arizona
India, Mysore
Public Health Research Institute of India
Sales-Martinez, Sabrina
United States, Miami
Florida International University
Campa, Adriana L.
United States, Miami
Florida International University
Baum, Marianna Karas
United States, Miami
Florida International University
Statistics
Citations: 5
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1080/09540121.2021.1896660
ISSN:
09540121
Research Areas
Infectious Diseases
Mental Health
Substance Abuse
Study Design
Cohort Study