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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults
PLoS ONE, Volume 9, No. 5, Article e93919, Year 2014
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Description
Background: Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women. Methods and findings: Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = 0.001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05). Conclusions: Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations. © 2014 Miri-Dashe et al.
Authors & Co-Authors
Miri-Dashe, Timzing
Nigeria, Jos
Institute of Human Virology
Nigeria, Abuja
Institute of Human Virology - Nigeria
Osawe, Sophia
Nigeria, Jos
Institute of Human Virology
Nigeria, Abuja
Institute of Human Virology - Nigeria
Daniel, Monday Tokdung Nenbammun
Nigeria, Jos
Institute of Human Virology
Nigeria, Abuja
Medical Laboratory Science Council of Nigeria
Choji, Rahila Pam
Nigeria, Jos
Institute of Human Virology
Mamman, Ille
Nigeria, Jos
Institute of Human Virology
United States, Baltimore
University of Maryland School of Medicine
Deme, Kurt
Nigeria
Plateau State Specialist Hospital # 13
Damulak, Dapus Obadiah
Nigeria
Plateau State Specialist Hospital # 13
Abimiku, Alash'Le G.
Nigeria, Jos
Institute of Human Virology
Nigeria, Abuja
Institute of Human Virology - Nigeria
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0093919
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Male
Female