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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis
Molecular Psychiatry, Volume 28, No. 3, Year 2023
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Description
Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness. © 2022, The Author(s).
Authors & Co-Authors
Kelly, Sinéad M.
United Kingdom, London
King's College London
Nerland, Stener
Norway, Oslo
Diakonhjemmet Sykehus
Norway, Oslo
Universitetet I Oslo
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Alloza, Clara
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Ambrogi, Sonia
Italy, Rome
Irccs Fondazione Santa Lucia
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Arango, Celso
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Madrid
Universidad Complutense de Madrid
Banaj, Nerisa
Italy, Rome
Irccs Fondazione Santa Lucia
Bearden, Carrie E.
United States, Los Angeles
University of California, Los Angeles
Berk, Michael
Australia, Geelong
Barwon Health
Chye, Yann
Australia, Clayton
Monash University
Crespo-Facorro, Benedicto
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Díaz-Caneja, M. C.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Madrid
Universidad Complutense de Madrid
Gurholt, Tiril P.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
James, Anthony C.
United Kingdom, Oxford
Warneford Hospital
United Kingdom, Oxford
University of Oxford
Janssen, Joost
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Jönsson, Erik Gunnar
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Kochunov, Peter V.
United States, Baltimore
University of Maryland School of Medicine
Piras, Fabrizio
Italy, Rome
Irccs Fondazione Santa Lucia
Spalletta, Gianfranco
Italy, Rome
Irccs Fondazione Santa Lucia
United States, Houston
Baylor College of Medicine
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
Tordesillas-Gutiérrez, Diana
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Santander
Csic-uc - Instituto de Física de Cantabria Ifca
Vecchio, Daniela
Italy, Rome
Irccs Fondazione Santa Lucia
Wedervang–Resell, Kirsten
Norway, Oslo
Oslo Universitetssykehus
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Agartz, Ingrid A.
Norway, Oslo
Diakonhjemmet Sykehus
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 7
Authors: 26
Affiliations: 22
Identifiers
Doi:
10.1038/s41380-022-01901-3
ISSN:
13594184
Research Areas
Mental Health
Study Design
Cohort Study
Case-Control Study
Participants Gender
Male
Female