Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment
Supportive Care in Cancer, Volume 21, No. 11, Year 2013
Notification
URL copied to clipboard!
Description
Purpose: Assessment of health-related quality of life (HRQOL) is critical to effective delivery of palliative care in patients with advanced cancer. The current study analyzes relationships between baseline social determinants of health and medical factors, and self-reported HRQOL in patients with bone metastases receiving palliative radiotherapy. Methods and materials: Advanced cancer patients referred for radiotherapy treatment of bone metastases completed the EORTC QLQ-C30 questionnaire in multiple outpatient clinics internationally. Demographics and social determinants were collected as baseline information. Univariate and Bonferroni-adjusted multivariate linear regression analyses were used to detect significant correlations between baseline determinants and different HRQOL domains. Results: Karnofsky Performance Status (KPS) was correlated with better physical (p = 0.0002), role (p < 0.0001), emotional (p < 0.0001), and social (p < 0.0001) functioning, and global health scores (p = 0.0015) and predicted lower symptom scores for fatigue (p < 0.0001), pain (p < 0.0001), appetite loss (p < 0.0001), and constipation (p < 0.0001). Increased age was predictive of better social functioning (p < 0.0001) and less insomnia (p = 0.0036), higher education correlated with better global health status (p = 0.0043), and patients who were employed or retired had improved physical functioning (p = 0.0004 and p = 0.0030, respectively) and less financial challenges compared to patients who were unemployed (p = 0.0005). Conclusions: Baseline KPS had the greatest influence on EORTC QLQ-C30 domain scores. Age, education level, and employment status had significant impacts, although on fewer domains. Further studies that investigate baseline determinants are worthwhile to clarify relationships in order to care for patients more effectively at the end of life. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Lam, Kinsey
Canada, Toronto
University of Toronto
Chow, Edwardedward L.W.
Canada, Toronto
University of Toronto
Zhang, Liying
Canada, Toronto
University of Toronto
Wong, Erin T.
Canada, Toronto
University of Toronto
Bedard, Gillian
Canada, Toronto
University of Toronto
Fairchild, Alysa M.
Canada, Edmonton
University of Alberta
Vassiliou, Vassilios P.
Cyprus, Nicosia
Bank of Cyprus Group Oncology Centre
el-Din, Mohamed Alm
Egypt, Tanta
Tanta University Hospitals
Jesus-Garcia, Reynaldo
Brazil, Sao Paulo
Universidade Federal de São Paulo
Kumar, Aswin
India, Thiruvananthapuram
Regional Cancer Center
Forges, Fabien
France, Saint-etienne
Université Jean Monnet Saint Etienne
Tseng, Lingming
Taiwan, Taipei
National Yang-ming University Taiwan
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Chie, Wei-Chu
Taiwan, Taipei
National Taiwan University
Bottomley, Andrew
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Statistics
Citations: 34
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.1007/s00520-013-1876-6
ISSN:
09414355
e-ISSN:
14337339
Research Areas
Cancer
Disability