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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of drug resistance mutations in naïve and ART-treated patients infected with HIV-1 in Yaounde, Cameroon
Journal of Medical Virology, Volume 84, No. 5, Year 2012
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Description
Currently the prevalence of HIV-1 infection in Cameroon is 5.1%, CRF02-AG subtype is responsible for about 50% of infections. Since an HIV-1 drug resistance test is not yet available widely, accurate data on the prevalence of resistant viral strains are missing. The objective of this study was to determine HIV-1 genetic diversity and to characterize HIV-1 mutations conferring drug resistance among antiretroviral therapy (ART)-naïve and ART-treated patients. A cohort of 239 patients infected with HIV were followed-up between January 2007 and July 2010 in Cameroon. Two hundred and sixteen plasma samples were sequenced for phylogenetic analysis and identification of drug resistance mutations in the HIV-1 pol region. A significant genetic diversity was found: Seven pure subtypes (A1, A3, D, F1, F2, G, H), nine circulating recombinant forms (CRFs: 01-AE, 02-AG, 06cpx, 09cpx, 11cpx, 13cpx, 16cpx, 18cpx, 37cpx) and one new unique recombinant form (URF) (G/F2). The rate of transmitted drug resistance (TDR) in naïve patients was 8.2% (4/49). Around 80% of patients failing a first-line ART harbored a virus with at least one resistance mutation to two antiretroviral (ARV) classes, and 36% of those failing a second-line regimen carried a virus with at least one resistant mutation to three ARV classes. The high level of drug resistance observed in the cohort is alarming because this occurred as a result of only few years of treatment. Adherence to therapy, adequate education of physicians, and the appropriate use of genotypic resistance assay are critical points of intervention for the improvement of patient care. © 2012 Wiley Periodicals, Inc.
Authors & Co-Authors
Ceccarelli, Laura
Italy, Rome
Policlinico Tor Vergata
Salpini, Romina
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Moudourou, Sylvie
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Cento, Valeria
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Santoro, Maria Mercedes
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Fokam, Joseph
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Takou, Désiré Komego
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Nanfack, Aubin Joseph
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Dori, Luca
Italy, Rome
Policlinico Tor Vergata
Torimiro, Judith Ndongo
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Sarmati, Loredana
Italy, Rome
Policlinico Tor Vergata
Andreoni, Massimo G.
Italy, Rome
Policlinico Tor Vergata
Perno, Carlo Federico
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Colizzi, Vittorio C.
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Cappelli, Giulia
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Italy, Rome
Consiglio Nazionale Delle Ricerche
Statistics
Citations: 39
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.23244
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
Cameroon