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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection
AIDS Research and Human Retroviruses, Volume 27, No. 5, Year 2011
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Description
Recent studies suggest that natural killer T (NKT) cells play a role in early antiviral pathogenesis and are rapidly depleted in chronic human immunodeficiency virus type 1 (HIV-1) clade B infection. We aimed to characterize the phenotypic and functional characteristics of NKT cells in HIV-1 clade C-infected Africans at different stages of HIV-1 disease. NKT cell frequencies, subsets, and ex vivo effector functions were assessed using multiparametric flow cytometry in a cross-sectional analysis of cryopreserved peripheral blood mononuclear cells from a cohort of 53 HIV-1 clade C chronically infected South African adults with CD4 T cell counts ranging from 94 to 839 cells/μl. We observed a significant decline of NKT cell numbers in advanced HIV-1 disease as well as activation and functional impairment of NKT cells in individuals with low CD4 T cell counts. The loss of NKT cells was largely driven by a reduction in the CD4+ and CD4-CD8- NKT cell subsets in advanced disease. These findings demonstrate significant impairment of the NKT cell compartment in progressive HIV-1 clade C disease that might play an important role in the modulation of immune function in HIV-1 infection. © Copyright 2011, Mary Ann Liebert, Inc.
Authors & Co-Authors
Mureithi, Marianne Wanjiru
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Massachusetts Institute of Technology
Cohen, Kristen W.
United States, Cambridge
Massachusetts Institute of Technology
Moodley, Ramona
South Africa, Durban
The Nelson R. Mandela Medical School
Poole, Danielle
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Massachusetts Institute of Technology
Mncube, Zenele
South Africa, Durban
The Nelson R. Mandela Medical School
Kasmar, Anne G.
United States, Boston
Brigham and Women's Hospital
Moody, David Branch
United States, Boston
Brigham and Women's Hospital
Goulder, Philip Jeremy Renshaw
South Africa, Durban
The Nelson R. Mandela Medical School
United Kingdom, Oxford
Nuffield Department of Medicine
Walker, Bruce D.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Massachusetts Institute of Technology
United States, Chevy Chase
Howard Hughes Medical Institute
Altfeld, Marcus A.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Massachusetts Institute of Technology
Ndung'u, Thumbi P.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Massachusetts Institute of Technology
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 23
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1089/aid.2010.0237
ISSN:
08892229
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study