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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations
Genome Research, Volume 26, No. 2, Year 2016
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Description
An open question in the history of human migration is the identity of the earliest Eurasian populations that have left contemporary descendants. The Arabian Peninsula was the initial site of the out-of-Africa migrations that occurred between 125,000 and 60,000 yr ago, leading to the hypothesis that the first Eurasian populations were established on the Peninsula and that contemporary indigenous Arabs are direct descendants of these ancient peoples. To assess this hypothesis, we sequenced the entire genomes of 104 unrelated natives of the Arabian Peninsula at high coverage, including 56 of indigenous Arab ancestry. The indigenous Arab genomes defined a cluster distinct from other ancestral groups, and these genomes showed clear hallmarks of an ancient out-of-Africa bottleneck. Similar to other Middle Eastern populations, the indigenous Arabs had higher levels of Neanderthal admixture compared to Africans but had lower levels than Europeans and Asians. These levels of Neanderthal admixture are consistent with an early divergence of Arab ancestors after the outof-Africa bottleneck but before the major Neanderthal admixture events in Europe and other regions of Eurasia. When compared to worldwide populations sampled in the 1000 Genomes Project, although the indigenous Arabs had a signal of admixture with Europeans, they clustered in a basal, outgroup position to all 1000 Genomes non-Africans when considering pairwise similarity across the entire genome. These results place indigenous Arabs as the most distant relatives of all other contemporary non-Africans and identify these people as direct descendants of the first Eurasian populations established by the out-of-Africa migrations. © 2016 Rodriguez-Flores et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4728368/bin/supp_26_2_151__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4728368/bin/supp_gr.191478.115_Supplemental_Data.pdf
Authors & Co-Authors
Rodríguez Flores, Juan Lorenzo
United States, New York
Weill Cornell Medicine
Fakhro, Khalid Adnan
Qatar, Doha
Sidra Medicine
Qatar, Doha
Weill Cornell Medicine-qatar
Agosto-Pérez, Francisco J.
United States, New York
Weill Cornell Medicine
United States, Ithaca
Cornell University
Robay, Amal
Qatar, Doha
Weill Cornell Medicine-qatar
Malek, Joel A.
Qatar, Doha
Weill Cornell Medicine-qatar
Suhre, Karsten
Qatar, Doha
Weill Cornell Medicine-qatar
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Al-Marri, Ajayeb Nabet
Qatar, Doha
Hamad Medical Corporation
Abi Khalil, Charbel
Qatar, Doha
Weill Cornell Medicine-qatar
Zirie, Mahmoud Ali
Qatar, Doha
Hamad Medical Corporation
Jayyousi, Amin A.
Qatar, Doha
Hamad Medical Corporation
Salit, Jacqueline
United States, New York
Weill Cornell Medicine
Keinan, Alon
United States, Ithaca
Cornell University
Clark, Andrew G.
United States, Ithaca
Cornell University
Crystal, Ronald G.
United States, New York
Weill Cornell Medicine
Mezey, Jason G.
United States, New York
Weill Cornell Medicine
United States, Ithaca
Cornell University
Statistics
Citations: 67
Authors: 16
Affiliations: 5
Identifiers
Doi:
10.1101/gr.191478.115
ISSN:
10889051
Research Areas
Health System And Policy