Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
25-hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings
Journal of Infectious Diseases, Volume 210, No. 2, Year 2014
Notification
URL copied to clipboard!
Description
Background. Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods. A case-cohort study (N = 411) was nested within a randomized cART trial of 1571 cART-naive adults in 8 resource-limited settings and the United States. The primary outcome (WHO stage 3/4 disease or death within 96 weeks of cART initiation) was met by 192 cases, and 152 and 29 cases met secondary outcomes of virologic and immunologic failure. We studied prevalence and risk factors for baseline low 25(OH)D (<32 ng/mL) and examined associated outcomes using proportional hazard models. Results. Low 25(OH)D prevalence was 49% and ranged from 27% in Brazil to 78% in Thailand. Low 25(OH)D was associated with high body mass index (BMI), winter/spring season, country-race group, and lower viral load. Baseline low 25(OH)D was associated with increased risk of human immunodeficiency virus (HIV) progression and death (adjusted hazard ratio (aHR) 2.13; 95% confidence interval [CI], 1.09-4.18) and virologic failure (aHR 2.42; 95% CI, 1.33-4.41). Conclusions. Low 25(OH)D is common in diverse HIV-infected populations and is an independent risk factor for clinical and virologic failure. Studies examining the potential benefit of vitamin D supplementation among HIV patients initiating cART are warranted. © 2014 The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4141201/bin/supp_210_2_244__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4141201/bin/supp_jiu259_jiu259supp_figure.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4141201/bin/supp_jiu259_jiu259supp_table.docx
Authors & Co-Authors
Havers, Fiona P.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
Smeaton, Laura M.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gupte, Nikhil Anil
United States, Baltimore
Johns Hopkins School of Medicine
India, Pune
B.j. Medical College, Pune
Detrick, Barbara
United States, Baltimore
Johns Hopkins School of Medicine
Bollinger, Robert Cyril
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
India, Pune
B.j. Medical College, Pune
Hakim, James Gita
Zimbabwe, Harare
University of Zimbabwe
Kumarasamy, Nagalingeswaran
India, Chennai
Vhs Medical Centre India
Andrade, Adriana S.A.
United States, Baltimore
Johns Hopkins School of Medicine
Christian, Parul S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Lama, Javier R.
Peru, Lima
Asociación Civil Impacta Salud y Educación
Campbell, Thomas B.
United States, Aurora
University of Colorado Anschutz Medical Campus
Gupta, Amita
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
India, Pune
B.j. Medical College, Pune
Statistics
Citations: 49
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/jiu259
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative