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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Novel genome sequences of cell-fusing agent virus allow comparison of virus phylogeny with the genetic structure of Aedes aegypti populations
Virus Evolution, Volume 6, No. 1, Article 6, Year 2020
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Description
Flaviviruses encompass not only medically relevant arthropod-borne viruses (arboviruses) but also insect-specific flaviviruses (ISFs) that are presumably maintained primarily through vertical transmission in the insect host. Interestingly, ISFs are commonly found infecting important arbovirus vectors such as the mosquito Aedes aegypti. Cell-fusing agent virus (CFAV) was the first described ISF of mosquitoes more than four decades ago. Despite evidence for widespread CFAV infections in A.aegypti populations and for CFAV potential to interfere with arbovirus transmission, little is known about CFAV evolutionary history. Here, we generated six novel CFAV genome sequences by sequencing three new virus isolates and subjecting three mosquito samples to untargeted viral metagenomics. We used these new genome sequences together with published ones to perform a global phylogenetic analysis of CFAV genetic diversity. Although there was some degree of geographical clustering among CFAV sequences, there were also notable discrepancies between geography and phylogeny. In particular, CFAV sequences from Cambodia and Thailand diverged significantly, despite confirmation that A.aegypti populations from both locations are genetically close. The apparent phylogenetic discrepancy between CFAV and its A.aegypti host in Southeast Asia indicates that other factors than host population structure shape CFAV genetic diversity. © 2020 Oxford University Press. All rights reserved.
Authors & Co-Authors
Baidaliuk, Artem
France, Paris
Institut Pasteur, Paris
France, Paris
Sorbonne Université
Lequime, Sebastian Dsign©bastian
France, Paris
Institut Pasteur, Paris
Moltini-Conclois, Isabelle
France, Paris
Institut Pasteur, Paris
Dabo, Stéphanie
France, Paris
Institut Pasteur, Paris
Dickson, Laura B.
France, Paris
Institut Pasteur, Paris
Prot, Matthieu
France, Paris
Institut Pasteur, Paris
Duong, Veasna
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Dussart, Philippe
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Boyer, Sebastien
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Shi, Chenyan
Belgium, Leuven
Rega Institute for Medical Research
Matthijnssens, Jelle
Belgium, Leuven
Rega Institute for Medical Research
Guglielmini, Julien
France, Paris
Institut Pasteur, Paris
Gloria-Soria, Andrea
United States, New Haven
Connecticut Agricultural Experiment Station
United States, New Haven
Yale University
Simon-Lorière, Etienne
France, Paris
Institut Pasteur, Paris
Lambrechts, Louis
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 21
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1093/VE/VEAA018
ISSN:
20571577
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study