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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Global extraintestinal pathogenic escherichia coli (Expec) lineages
Clinical Microbiology Reviews, Volume 32, No. 3, Article e00135-18, Year 2019
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Description
Extraintestinal pathogenic Escherichia coli (ExPEC) strains are responsible for a majority of human extraintestinal infections globally, resulting in enormous direct medical and social costs. ExPEC strains are comprised of many lineages, but only a subset is responsible for the vast majority of infections. Few systematic surveillance systems exist for ExPEC. To address this gap, we systematically reviewed and meta-analyzed 217 studies (1995 to 2018) that performed multilocus sequence typing or whole-genome sequencing to genotype E. coli recovered from extraintestinal infections or the gut. Twenty major ExPEC sequence types (STs) accounted for 85% of E. coli isolates from the included studies. ST131 was the most common ST from 2000 onwards, covering all geographic regions. Antimicrobial resistance-based isolate study inclusion criteria likely led to an overestimation and underestimation of some lineages. European and North American studies showed similar distributions of ExPEC STs, but Asian and African studies diverged. Epidemiology and population dynamics of ExPEC are complex; summary proportion for some STs varied over time (e.g., ST95), while other STs were constant (e.g., ST10). Persistence, adaptation, and predominance in the intestinal reservoir may drive ExPEC success. Systematic, unbiased tracking of predominant ExPEC lineages will direct research toward better treatment and prevention strategies for extraintestinal infections. © 2019 American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Manges, Amee R.
Canada, Vancouver
The University of British Columbia
Geum, Hyun-min
Canada, Vancouver
The University of British Columbia
Edens, Thaddeus J.
Canada, Vancouver
Devil's Staircase Consulting
Pitout, Johann D.D.
Canada, Calgary
Calgary Laboratory Services
Canada, Calgary
University of Calgary
Statistics
Citations: 284
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1128/CMR.00135-18
ISSN:
08938512
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study