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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Urbanization associates with restricted gut microbiome diversity and delayed maturation in infants
iScience, Volume 26, No. 11, Article 108136, Year 2023
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Description
Alterations of the microbiome are linked to increasingly common diseases such as obesity, allergy, and inflammatory bowel disease. Post-industrial lifestyles are thought to contribute to the gut microbiome alterations that cause or aggravate these diseases. Comparing communities across the industrialization spectrum can reveal associations between gut microbiome alterations and lifestyle and health, and help pinpoint which specific aspect of the post-industrial lifestyle is linked to microbiome alterations. Here, we compare the gut microbiomes of 60 mother and infant pairs from rural and urban areas of Senegal over two time points. We find that urban mothers, who were more frequently overweight, had different gut microbiome compositions than rural mothers, showing an expansion of Lachnospiraceae and Enterobacter. Urban infants, on the other hand, showed a delayed gut microbiome maturation and a higher susceptibility to infectious diseases. Thus, we identify new microbiome features associated with industrialization, whose association with disease may be further investigated. © 2023 The Authors
Authors & Co-Authors
Brot, Loïc
France, Paris
Centre de Recherche Saint-antoine
Seck, Sidy Mohamed
Senegal, Saint-louis
Université Gaston Berger de Saint-louis
MacIa, Enguerran
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
France, Paris
Cnrs Centre National de la Recherche Scientifique
Seksik, Philippe
France, Paris
Centre de Recherche Saint-antoine
Statistics
Authors: 4
Affiliations: 7
Identifiers
Doi:
10.1016/j.isci.2023.108136
ISSN:
25890042
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Locations
Senegal