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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Community-based interventions to promote blood pressure control in a developing country: A cluster randomized trial
Annals of Internal Medicine, Volume 151, No. 9, Year 2009
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Description
Background: Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. Objective: To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adults. Design: Cluster randomized, 2 x 2 factorial, controlled trial. (ClinicalTrials. gov registration number: NCT00327574) Setting: 12 randomly selected communities in Karachi, Pakistan. Patients: 1341 patients 40 years or older with hypertension (systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or already receiving treatment). Measurements: Reduction in systolic blood pressure from baseline to end of follow-up at 2 years. Intervention: Family-based home health education (HHE) from lay health workers every 3 months and annual training of general practitioners (GPs) in hypertension management. Results: The age, sex, and baseline blood pressure-adjusted decrease in systolic blood pressure was significantly greater in the HHE and GP group (10.8 mm Hg [95% CI, 8.9 to 12.8 mm Hg]) than in the GP-only, HHE-only, or no intervention groups (5.8 mm Hg [CI, 3.9 to 7.7 mm Hg] in each; P < 0.001). The interaction between the main effects of GP training and HHE on the primary outcome approached significance (interaction P = 0.004 in intention-to-treat analysis and P = 0.044 in per-protocol analysis). Limitations: Follow-up blood pressure measurements were missing for 22% of patients. No mechanism was detected by which interventions lowered blood pressure. Conclusion: Family-based HHE delivered by trained lay health workers, coupled with educating GPs on hypertension, can lead to significant blood pressure reductions among patients with hypertension in Pakistan. Both strategies in combination may be feasible for upscaling within the existing health care systems of Indo-Asian countries. Primary Funding Source: Wellcome Trust. © 2009 American College of Physicians.
Authors & Co-Authors
Jafar, Tazeen Hasan
Pakistan, Karachi
The Aga Khan University Hospital
Hatcher, J.
Canada, Edmonton
Alberta Health Services
Poulter, Neil R.
United Kingdom, London
National Heart and Lung Institute
Islam, Md Tariqul
Pakistan, Karachi
The Aga Khan University Hospital
Hashmi, Shiraz
Pakistan, Karachi
The Aga Khan University Hospital
Qadri, Zeeshan
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Bux, Rasool
Pakistan, Karachi
The Aga Khan University Hospital
Khan, Ayesha
Pakistan, Karachi
The Aga Khan University Hospital
Jafary, Fahim H.
Pakistan, Karachi
The Aga Khan University Hospital
Hameed, Aamir
Pakistan, Karachi
The Aga Khan University Hospital
Khan, Ata
Pakistan, Karachi
The Aga Khan University Hospital
Badruddin, Salma H.
Pakistan, Karachi
Dha Phase Vi
Chaturvedi, Nish R.
United Kingdom, London
National Heart and Lung Institute
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1059/0003-4819-151-9-200911030-00004
ISSN:
00034819
e-ISSN:
15393704
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study